Investigating the effects of radiotherapy on circulating tumor cells in breast cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore how adjuvant radiotherapy affects circulating epithelial tumor cells (CETCs) in patients with non-metastatic breast carcinoma, focusing on differences based on patient age. Blood samples will be collected at various time points after tumor resection and during radiotherapy to analyze the immunohistochemical characteristics of CETCs and their correlation with tumor-infiltrating lymphocytes. The study seeks to identify prognostic and predictive biomarkers that could inform treatment strategies for early-stage breast cancer patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Primary diagnosis histologically confirmed invasive breast carcinoma pT1-4 pN0 or pN+ cM0
* curative-intended breast-conserving therapy (BET) ± (neo-) adj. system therapy with subsequent adjuvant radiotherapy of the breast ± lymphatic drainage system planned
* informed consent of the patient

Exclusion Criteria:

* DCIS, Inflammatory breast carcinoma
* Recurrence situation
* Presence of distant metastases
* Second malignancies \< 10 years prior to diagnosis of breast carcinoma
* Prior exposure to radiotherapy

Where it's running

• Department of Radiooncology, Jena
  Jena, Germany Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.