Investigating the effects of Cushing's syndrome on fatty liver disease
Prévalence De La Stéato-fibrose Hépatique Dans Le Syndrome De Cushing
This study is testing how Cushing's syndrome affects the risk of developing fatty liver disease in adults who have the condition.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Angers Government |
| Locations | 6 sites (Angers and 5 other locations) |
| Trial ID | NCT05881005 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to explore the relationship between Cushing's syndrome and the development of Non-Alcoholic Fatty Liver Disease (NAFLD). It will involve patients over 18 years old who are actively diagnosed with Cushing's syndrome. The study will utilize hepatic MRI to assess liver conditions and the prevalence of hepatic steatosis in this patient population. The findings could provide insights into the metabolic complications associated with prolonged cortisol exposure.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who have an active diagnosis of Cushing's syndrome.
Not a fit: Patients with other chronic liver diseases or contraindications to MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of liver complications in patients with Cushing's syndrome, leading to better management strategies.
How similar studies have performed: While there is limited data on this specific relationship, previous studies have indicated a prevalence of hepatic steatosis in patients with Cushing's syndrome, suggesting potential for meaningful findings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 years * Active Cushing's syndrome Exclusion Criteria: * Other common causes of chronic liver disease (HBV, HCV, haemochromatosis, alcohol) * Contraindication to MRI
Where this trial is running
Angers and 5 other locations
- University Hospital, Angers — Angers, France (Recruiting)
- University Hospital, Bordeaux — Bordeaux, France (Recruiting)
- University Hospital, Brest — Brest, France (Recruiting)
- University Hospital, Grenoble — Grenoble, France (Recruiting)
- University Hospital, Nantes — Nantes, France (Recruiting)
- University Hospital, Rennes — Rennes, France (Not_yet_recruiting)
Study contacts
- Principal investigator: Claire BRIET — University Hospital of Anger
- Study coordinator: Claire BRIET
- Email: claire.briet@chu-angers.fr
- Phone: 02 41 35 36 37
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.