Investigating the effects of Cushing's syndrome on fatty liver disease
Official title: Prévalence de la stéato-fibrose hépatique Dans le Syndrome de Cushing
Run by University Hospital, Angers · NCT05881005 · Data updated 2026-11-12
This study is testing how Cushing's syndrome affects the risk of developing fatty liver disease in adults who have the condition.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University Hospital, Angers Government |
| Locations | 7 sites (Angers and 6 other locations) |
| Status | Recruiting |
| Started | September 28, 2023 |
| Main results expected | September 28, 2027 |
| Study ends | September 28, 2029 |
| Registry record updated | July 10, 2026 |
| Trial ID | NCT05881005 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old who have an active diagnosis of Cushing's syndrome.
✕Probably not a fit
Patients with other chronic liver diseases or contraindications to MRI will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to explore the relationship between Cushing's syndrome and the development of Non-Alcoholic Fatty Liver Disease (NAFLD). It will involve patients over 18 years old who are actively diagnosed with Cushing's syndrome. The study will utilize hepatic MRI to assess liver conditions and the prevalence of hepatic steatosis in this patient population. The findings could provide insights into the metabolic complications associated with prolonged cortisol exposure.
Why it matters
Potential benefit: If successful, this study could enhance understanding of liver complications in patients with Cushing's syndrome, leading to better management strategies.
How similar studies have gone: While there is limited data on this specific relationship, previous studies have indicated a prevalence of hepatic steatosis in patients with Cushing's syndrome, suggesting potential for meaningful findings.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 years * Active Cushing's syndrome Exclusion Criteria: * Other common causes of chronic liver disease (HBV, HCV, haemochromatosis, alcohol) * Contraindication to MRI
Where it's running
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University Hospital, Angers
Angers, France Recruiting -
University Hospital, Bordeaux
Bordeaux, France Recruiting -
University Hospital, Brest
Brest, France Recruiting -
University Hospital, Grenoble
Grenoble, France Recruiting -
University Hospital, Lille
Lille, France Recruiting -
University Hospital, Nantes
Nantes, France Recruiting
Show 1 more location
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University Hospital, Nancy
Vandœuvre-lès-Nancy, France Recruiting
Study contacts
- Principal investigator: Claire BRIET — University Hospital of Anger
- Study coordinator: Claire BRIET
- Email: claire.briet@chu-angers.fr
- Phone: 02 41 35 36 37
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.