Clinical trial Recruiting at 7 sites Interventional Ages 18 and up

Investigating the effects of Cushing's syndrome on fatty liver disease

Official title: Prévalence de la stéato-fibrose hépatique Dans le Syndrome de Cushing

Run by University Hospital, Angers · NCT05881005 · Data updated 2026-11-12

This study is testing how Cushing's syndrome affects the risk of developing fatty liver disease in adults who have the condition.

More Cushing Syndrome trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorUniversity Hospital, Angers
Government
Locations7 sites (Angers and 6 other locations)
StatusRecruiting
StartedSeptember 28, 2023
Main results expectedSeptember 28, 2027
Study endsSeptember 28, 2029
Registry record updatedJuly 10, 2026
Trial IDNCT05881005 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults over 18 years old who have an active diagnosis of Cushing's syndrome.

Probably not a fit

Patients with other chronic liver diseases or contraindications to MRI will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to explore the relationship between Cushing's syndrome and the development of Non-Alcoholic Fatty Liver Disease (NAFLD). It will involve patients over 18 years old who are actively diagnosed with Cushing's syndrome. The study will utilize hepatic MRI to assess liver conditions and the prevalence of hepatic steatosis in this patient population. The findings could provide insights into the metabolic complications associated with prolonged cortisol exposure.

Why it matters

Potential benefit: If successful, this study could enhance understanding of liver complications in patients with Cushing's syndrome, leading to better management strategies.

How similar studies have gone: While there is limited data on this specific relationship, previous studies have indicated a prevalence of hepatic steatosis in patients with Cushing's syndrome, suggesting potential for meaningful findings.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age \> 18 years
* Active Cushing's syndrome

Exclusion Criteria:

* Other common causes of chronic liver disease (HBV, HCV, haemochromatosis, alcohol)
* Contraindication to MRI

Where it's running

  • University Hospital, Angers
    Angers, France
    Recruiting
  • University Hospital, Bordeaux
    Bordeaux, France
    Recruiting
  • University Hospital, Brest
    Brest, France
    Recruiting
  • University Hospital, Grenoble
    Grenoble, France
    Recruiting
  • University Hospital, Lille
    Lille, France
    Recruiting
  • University Hospital, Nantes
    Nantes, France
    Recruiting
Show 1 more location
  • University Hospital, Nancy
    Vandœuvre-lès-Nancy, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  • Osilodrostat for high blood pressure caused by Cushing's syndrome

    This study tests whether osilodrostat can lower high blood pressure in adults with Cushing's syndrome-related hypercortisolemia.

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  • Normal ranges and diagnostic cut-offs for salivary cortisol

    This project will test two saliva cortisol methods — a lab LC‑MS assay and a rapid fluorescence immunoassay — to find normal ranges and the best diagnostic cut-offs for adults with suspected Cushing syndrome or adrenal insufficiency.

    Recruiting Shanghai 6th People's Hospital · Shanghai, Shanghai Municipality · NCT07168122

  • Gepaktiv compared with UDCA and Ademetionine for MAFLD with enlarged liver

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    Recruiting Phenomen Pharma · Tyumen, Tyumen Oblast · NCT07068191

  • Using modified Desmopressin for better imaging in Cushing syndrome

    This study is testing a new way to use a modified form of Desmopressin to improve imaging for people with Cushing syndrome, helping doctors better see and understand pituitary tumors before surgery.

    Recruiting Post Graduate Institute of Medical Education and Research, Chandigarh · Chandigarh · NCT06962202

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.