Investigating the effects of a glucagon-like peptide-1 receptor agonist on adrenal function in healthy males

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines how a single dose of the glucagon-like peptide-1 receptor agonist semaglutide affects the hypothalamo-pituitary-adrenal axis and cortisol levels in healthy male volunteers. Participants will receive either semaglutide or a placebo to assess the drug's impact on stress hormones. The study focuses on understanding adrenal function and its regulation in response to this medication. Healthy males aged 18-60 with a specific BMI range will be recruited for this investigation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy male volunteers aged 18-60 years
* BMI 18.5-30 kg/m2
* No regular medication

Exclusion Criteria:

* participation in a trial with investigational drugs within 30 days
* vigorous physical exercise within 24 hours before the study participation
* alcohol intake within 24 hours before the study participation
* a history of intake of glucocorticoids or GLP-1 RA within the last 8 weeks.
* Known allergy towards GLP-1 RA

Where it's running

• University Hospital Basel
  Basel, Switzerland Recruiting

Study contacts

• Study coordinator: Sandrine Urwyler, PD Dr. med.
• Email: sandrine.urwyler@usb.ch
• Phone: +41 61 265 50 78

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.