Investigating the connection between gut and lung health in children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study at the Royal Hospital for Children in Glasgow aims to explore the gut-lung axis in children with respiratory and gastrointestinal conditions using a multi-omics approach. It consists of two parts: a cross-sectional analysis comparing the gut and lung microbiomes of children with respiratory or GI issues to those without, and a longitudinal assessment of the effects of biologics on the gut-lung axis in children with asthma. The study seeks to establish correlations and validate the bidirectional relationship between gut and lung microbiomes in pediatric patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Any infant/child/young person admitted to the RHC, Glasgow for an elective bronchoscopy or GI endoscopy.
* Any infant/child attending for an emergency/elective orthopaedic operation without active respiratory or gastrointestinal conditions or receiving treatment for either condition. (Age range birth to 16 years for all groups recruited).
* Any child attending respiratory department at RHC who can induce sputum and is having a blood sample taken, with latter part of standard of care.
* Any infant/child/young person admitted to RHC for a clinical care appointment with Asthma/wheeze before commencement of biologics therapy (treatment group).
* Any child admitted to RHC with asthma/wheeze not indicated for biologic therapy (asthma control group).

Exclusion Criteria:

* Use of antibiotics by the day of admission or have used antibiotics in the previous month (unless prophylactic antibiotics \> 1 month use).
* Any person 17 years old and above.
* Any child known to be infected with, or at high risk of having had exposure to HIV, hepatitis B or hepatitis C viruses
* . Any child and/or parent/guardian who cannot understand the English language where consent would be unethical.
* Any child with Asthma currently receiving Biologics therapy (unless recruited via bronchoscopy route).

Where it's running

• NHS Greater Glasgow and Clyde: Royal Hospital for children, Glasgow
  Glasgow, United Kingdom Recruiting

Study contacts

• Principal investigator: Ross J Langley, MRCPCH — NHS Greater Glasgow and Clyde Board HQ
• Study coordinator: Ross J Langley, MRCPCH
• Email: ross.langley@ggc.scot.nhs.uk
• Phone: 0141 451 6683

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• E-health intervention to reduce smoking exposure in children

  This study is testing a new app for parents to help reduce secondhand smoke exposure for children under six years old and see if it improves their health.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT06311162

• Observing symptoms in children with first-onset bronchial asthma

  This study looks at how asthma shows up in kids and teens aged 3 to 18, especially if they have unusual symptoms like a chronic cough, to see if a specific questionnaire can help spot these cases better.

  Recruiting Charles University, Czech Republic · Prague · NCT06201494

• Soy isoflavones for infants at risk of asthma

  This study is testing if giving soy isoflavones to infants at high risk for asthma can help reduce their chances of developing the condition compared to a placebo.

  Recruiting at 2 sites Phase 2 Ann & Robert H Lurie Children's Hospital of Chicago · Chicago, Illinois and 1 other locations · NCT05667701

• N-WATCH: Can a simple breath device help monitor asthma in kids

  This study tests the N-Tidal C device to see if it helps monitor asthma in children aged 5 to under 16 who have wheeze or asthma and are not critically ill.

  Recruiting at 2 sites University of Nottingham · Nottingham, Nottinghamshire and 1 other locations · NCT07833826

• COPD self-management app test to see if it helps people get the best medication and control symptoms

  This trial tests whether the mySMARTCOPD app with an algorithm can help adults with COPD use the most appropriate inhaled therapy to control symptoms and reduce flare-ups.

  Recruiting Phase 1 University of Southampton · Southampton, England · NCT07797985

• Smart Inhaler Use at Home for Adolescents with IDD and Asthma

  This study tests whether daily use of active smart inhalers at home helps adolescents with intellectual disabilities manage asthma better.

  Recruiting Children's Hospital Los Angeles · Los Angeles, California · NCT07746921

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.