Investigating the cognitive effects of surviving COVID-19
Neural and Cognitive Consequences of COVID-19 Survival
This study is trying to see how surviving COVID-19 affects thinking and mood in people by looking at their brain activity and mental health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | San Francisco Veterans Affairs Medical Center Federal |
| Locations | 1 site (San Francisco, California) |
| Trial ID | NCT06208943 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the neural and cognitive consequences experienced by individuals who have survived COVID-19. By utilizing advanced neuroimaging techniques such as EEG and MRI, along with psychological assessments, the study seeks to identify ongoing cognitive deficits, depression, and anxiety in these patients. The research will analyze brain structure and function, as well as blood markers that may indicate neurological damage. The findings will help understand the pathophysiology of 'COVID brain' and inform future interventions.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 18-70 who have confirmed COVID-19 infection at least 3 months prior and meet MRI safety criteria.
Not a fit: Patients with past or present neurological problems or significant medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and management of cognitive impairments in COVID-19 survivors.
How similar studies have performed: Other studies have indicated cognitive impairments in COVID-19 survivors, suggesting that this approach is relevant and timely.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Our studies require some in-person visits to our research lab, located at 42nd Ave and Clement St in San Francisco. * Because this study includes an MRI, part of the screening process will be to ensure you don't have any metal in your body, you do not have head or neck tattoos, and you are comfortable inside the MRI scanner. * 18-70 years with a confirmed COVID infection at least 3 months ago. * Negative metal screen for MRI safety * Normal (or corrected to normal) vision Exclusion Criteria: * Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive symptoms) * Loss of consciousness (LOC) greater than 30 minutes or any LOC with neurologic symptoms * Major medical conditions (e.g., seizures disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology) * Substance dependence, within the past year, or failed urine toxicology on the day of neuroimaging sessions * Known claustrophobia * Current pregnancy * IQ estimate \< 70
Where this trial is running
San Francisco, California
- San Francisco Heathcare System — San Francisco, California, United States (Recruiting)
Study contacts
- Principal investigator: Judith M Ford, PhD — University of California, San Francisco
- Study coordinator: Kaitlyn L Dal Bon, BA
- Email: kaitlyn.dalbon@ucsf.edu
- Phone: (415) 629-9514
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.