Investigating the CLOCK gene's impact on weight loss in obese individuals
Investigation of the Relationship Between Weight Loss Diet and Circadian Gene CLOCK 3111T/C Polymorphism
Hacettepe University · NCT05750732
This study is testing how a specific gene might affect weight loss and eating habits in people who are overweight or obese.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 20 Years to 50 Years |
| Sex | All |
| Sponsor | Hacettepe University (other) |
| Locations | 1 site (Ankara) |
| Trial ID | NCT05750732 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between the CLOCK 3111T/C gene variant and various factors such as nutritional habits, sleep quality, and biochemical parameters in overweight or obese individuals. It will assess whether the frequency of this gene variant differs between normal weight and overweight/obese individuals, and how it affects their response to a weight loss diet. Participants will complete a questionnaire to evaluate their eating habits and adherence to a Mediterranean diet, providing insights into the genetic influences on weight management.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 20-50 with a BMI between 25-40 kg/m2 who are overweight or obese.
Not a fit: Patients with type 1 diabetes, severe endocrine disorders, or those who have undergone bariatric surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to personalized weight loss strategies based on genetic profiles.
How similar studies have performed: Other studies have shown promising results in understanding the genetic factors influencing obesity and weight loss, suggesting this approach has potential.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Be in the 20-50 age range * BMI in the range of 25-40 kg/m2 for the study group * BMI of 18.5-24.9 kg/m2 for the control group Exclusion Criteria: * Those with type 1 diabetes * Those with Type 2 diabetes who take insulin therapy or use oral diabetes medication * Those who use drugs for weight loss * Those with unstable cardiovascular disease * Those with kidney or liver failure * Presence of diagnosed malabsorption (celiac disease, Crohn's, ulcerative colitis) * Those who have undergone bariatric surgery * Those who are pregnant or breastfeeding * Menopausal women * Those who use corticosteroids * Those with severe endocrine disorders (hypothyroidism, hyperthyroidism, hypopituitarism) * Those with psychiatric or neurological disease * Weight change of \>5% in the last 6 months * Those with malignant tumors * Those with eating disorders * Shift workers * Relatives * People from different ethnic backgrounds
Where this trial is running
Ankara
- Hacettepe University — Ankara, Turkey (Türkiye) (RECRUITING)
Study contacts
- Principal investigator: Hande Gül Ulusoy Gezer, MSc — Hacettepe University
- Study coordinator: Hande Gül Ulusoy Gezer, MSc
- Email: handegululusoy@hacettepe.edu.tr
- Phone: +905357314604
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Polymorphism, Restriction Fragment Length, Obesity, obesity, circadian rhythm, polymorphism, CLOCK gene, weight loss diet