Investigating the characteristics of unilateral primary aldosteronism in Asians

Pathological Type，Gene Mutation and Clinical Characteristics of Unilateral Primary Aldosteronism，A Prospective Study

This study looks at the unique features and gene changes of unilateral primary aldosteronism in Asian patients to see how they relate to surgery results.

Quick facts

• Study type: Observational
• Enrollment: 100 (estimated)
• Ages: 18 Years to 80 Years
• Sex: All
• Sponsor: Chongqing Medical University (Academic / other)
• Locations: 1 site (Chongqing, Chongqing Municipality)
• Trial ID: NCT06597630 on ClinicalTrials.gov

What this trial studies

This observational study aims to explore the pathological features, gene mutations, and clinical characteristics of unilateral primary aldosteronism (UPA) in Asian patients. It seeks to clarify the relationship between these factors and surgical outcomes, building on previous findings that indicated a need for more comprehensive prospective studies. The research will involve analyzing tissue specimens through histopathology to identify different pathological types and their associated clinical phenotypes. The study is led by a multi-center expert team and aims to standardize the pathological classification of UPA.

Who should consider this trial

Good fit: Ideal candidates for this study are Asian patients aged 18-80 who have been diagnosed with unilateral primary aldosteronism and have undergone total adrenal resection.

Not a fit: Patients with bilateral disease or those who have undergone partial adrenalectomy may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnosis and treatment strategies for patients with unilateral primary aldosteronism.

How similar studies have performed: While previous studies have explored aspects of unilateral primary aldosteronism, this study's focus on the Asian population and its prospective design may provide novel insights.

Eligibility criteria

Inclusion Criteria:

1. No gender limitation;
2. Age 18-80 years old;
3. The patient was diagnosed with UPA and underwent total adrenal resection.

Exclusion Criteria:

1. Bilateral disease
2. Partial of no biochemical response in follow-up
3. partial adrenalectomy

Where this trial is running

Chongqing, Chongqing Municipality

• Qifu Li, PhD — Chongqing, Chongqing Municipality, China (Recruiting)

Study contacts

• Study coordinator: Li Qifu

Conditions Primary Aldosteronism; Pathological type; Gene mutation