Investigating respiratory viruses in patients with acute heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study enrolls adult patients admitted to the cardiology department with acute heart failure who have undergone a nasopharyngeal respiratory virus PCR test within 72 hours of admission. The study aims to analyze the detection rates of various respiratory viruses, including influenza, RSV, and coronaviruses, and to observe seasonal variations in their frequency. Additionally, it will assess how respiratory virus infections may influence the clinical presentation of acute heart failure. The findings could provide insights into the interplay between respiratory infections and heart failure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult aged 19 years or older admitted to the cardiology department with acute heart failure
* NT-proBNP \>300 pg/mL
* Clinician judgement of possible respiratory viral infection (fever \>38 degrees or cough, respiratory symptoms such as sputum or consolidation on x-ray or CRP \>5 mg/dL)
* Patients who have a nasopharyngeal swab for respiratory virus PCR test performed within 72 hours of admission for any of the 3 reasons

Exclusion Criteria:

* Patients with a clear other cause of acute heart failure (ex. ACS, bradycardia requiring a pacemaker, uncontrolled tachycardia, uncontrolled severe hypertension (SBP \>180mmHg or DBP \>110mmHg), haemoglobin \<7g/dL or AHF precipitated by medication non-adherence)
* If the cause of pulmonary oedema is prominently attributed to exacerbation of CKD
* If there is a clear other source of infection that can explain the fever

Where it's running

• Seoul National University Bundang Hospital
  Seongnam-si, Gyeonggi-do, South Korea Recruiting
• Samsung medical center
  Seoul, South Korea Recruiting
• Seoul ST. Mary's Hospital
  Seoul, South Korea Recruiting

Study contacts

• Study coordinator: Minjae Yoon, MD
• Email: minjae1677@gmail.com
• Phone: +82-10-6334-1917

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.