Investigating radiation effects on jaw complications in head and neck cancer patients
Is the Radiation Field, Dose and Fractionation Crucial for the Development of Mandibular Complications When Treating Malignancies in the Oropharyngeal Region?
This study looks at how different types of radiation treatment for head and neck cancer might affect jaw problems in patients after their treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Lund University Hospital Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Lund) |
| Trial ID | NCT05412849 on ClinicalTrials.gov |
What this trial studies
This observational study analyzes the relationship between radiation field, dose, and fractionation in patients treated for head and neck malignancies. It involves a retrospective review of medical records from patients who have undergone surgery and radiotherapy, focusing on complications such as osteoradionecrosis and jaw fractures. The study aims to determine how different radiation parameters may influence the healing capacity of the mandibular bone and the development of late complications. A minimum follow-up period of 12 months is required for patient inclusion.
Who should consider this trial
Good fit: Ideal candidates are adults diagnosed with head and neck malignancies who have received radiotherapy as part of their treatment.
Not a fit: Patients under 18 years of age or those with less than 12 months of follow-up will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved radiotherapy protocols that minimize complications for head and neck cancer patients.
How similar studies have performed: There is limited prior research on this specific relationship, making this study a novel investigation in the field.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of the head and neck malignancy * Must have recieved radiotherapy as primary treatment alone or combination treatment together with surgery Exclusion criteria * less than 12 months follow up * Under 18 years of age
Where this trial is running
Lund
- Skane University Hospital — Lund, Sweden (Recruiting)
Study contacts
- Principal investigator: Martin Bengtsson, PhD — Lund University Hospital
- Study coordinator: Philip Fransson, Msc
- Email: philip.fransson@skane.se
- Phone: 0046 761077255
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.