Investigating plaque calcium in carotid arteries using advanced MRI
In Vivo Atherosclerotic Plaque Calcium Characterization for Predicting Ruptured Plaques
Jinan Military General Hospital · NCT03849521
This study is testing a new type of MRI to see if it can better show calcium in carotid arteries for patients who might be at risk of stroke.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Sex | All |
| Sponsor | Jinan Military General Hospital (other) |
| Locations | 1 site (Jinan, Shandong) |
| Trial ID | NCT03849521 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the feasibility of using ultrashort echo time (UTE) MRI to enhance the imaging of carotid artery calcifications in vivo. By analyzing the correlation between UTE MRI findings and microcalcification in carotid plaques, the study seeks to identify characteristics of vulnerable atherosclerotic plaques that may lead to acute stroke. The research builds on previous findings that suggest active calcification processes in plaques could indicate higher risks for rupture and thrombosis. Patients referred for carotid endarterectomy or stenting will be enrolled, while those with certain exclusions will not participate.
Who should consider this trial
Good fit: Ideal candidates for this study are patients referred for carotid endarterectomy or stenting.
Not a fit: Patients with ferromagnetic implants, active medical devices, or those unable to undergo MRI due to claustrophobia will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved identification of high-risk atherosclerotic plaques, potentially reducing the incidence of acute strokes.
How similar studies have performed: While the approach of using UTE MRI for plaque characterization is relatively novel, previous studies have shown promise in imaging calcifications in atherosclerotic plaques.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients referred for carotid endarterectomy or stent were prospectively enrolled. Exclusion Criteria: Patients with ferromagnetic metal, active implants such as pacemakers, aneurysm clips, known claustrophobia, and those who were unable to provide informed consent were excluded from enrollment.
Where this trial is running
Jinan, Shandong
- Min Li — Jinan, Shandong, China (RECRUITING)
Study contacts
- Study coordinator: Zhen Yang, M.D.
- Email: taianyangzhen@126.com
- Phone: 18615658796
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Vulnerable Atherosclerotic Plaque, Atherosclerosis, Calcium, MR