Investigating pain response and opioid craving in individuals with opioid use disorder
Affective and Inflammatory Reactivity to Pain in Opioid Use Disorder
This study is testing how pain response and cravings for opioids are connected in adults with opioid use disorder to see if it can help improve their treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mclean Hospital Academic / other |
| Locations | 1 site (Belmont, Massachusetts) |
| Trial ID | NCT04190563 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the relationship between pain response and opioid craving in adults diagnosed with opioid use disorder. Participants will be randomly assigned to one of two educational sessions focused on pain management, followed by an assessment of their pain response. The goal is to understand how these factors interact and potentially influence treatment approaches for opioid use disorder.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with a diagnosis of opioid use disorder and chronic pain.
Not a fit: Patients currently experiencing opioid withdrawal or those receiving opioid analgesics for pain may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients with opioid use disorder, potentially reducing cravings and enhancing recovery.
How similar studies have performed: While the specific approach of this study is novel, similar studies have indicated that understanding pain and craving relationships can be beneficial in treating opioid use disorder.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age 18 years or older; * diagnosis of opioid use disorder * chronic pain * ability to read and provide informed consent Exclusion Criteria: * major psychiatric or medical condition that would interfere with participation * current opioid withdrawal * currently receiving opioid analgesic medication for pain * recent history of myocardial infarction or other serious cardiovascular condition * current peripheral neuropathy, active vasculitis or severe peripheral vascular disease * systematic inflammatory or autoimmune disorder * admitted to current treatment episode on an involuntary status
Where this trial is running
Belmont, Massachusetts
- McLean Hospital — Belmont, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Rebecca K McHugh, PhD — Mclean Hospital
- Study coordinator: Rebecca K McHugh, PhD
- Email: kmchugh@mclean.harvard.edu
- Phone: 617-855-2000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.