Investigating neutrophils in bone tumors
Assessment of the Presence, and Characterization, of Tumor-associated Neutrophils in Bone Sarcomas: Pilot Study
This study is looking at the role of certain immune cells in bone tumors to see how they might affect patients with osteosarcoma and chondrosarcoma.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 25 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Université de Reims Champagne-Ardenne Academic / other |
| Locations | 1 site (Reims) |
| Trial ID | NCT04867421 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the presence of tumor-associated neutrophils (TANs) in patients with osteosarcoma and chondrosarcoma. Adult patients undergoing surgery for these bone tumors will be invited to participate during their preoperative consultations. The study will involve collecting tumor samples and demographic data, as well as assessing the immune cell profile and PDL-1 status of the tumors. The findings could provide insights into the role of neutrophils in these cancers.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older diagnosed with osteosarcoma or chondrosarcoma who are scheduled for surgery.
Not a fit: Patients with medical histories that may compromise the study protocol or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the immune environment in bone sarcomas, potentially leading to improved treatment strategies.
How similar studies have performed: While the specific focus on neutrophils in bone sarcomas is novel, similar studies in other cancer types have shown promising results regarding the role of immune cells.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient of 18 years and more * Patient of the Orthopedic and Traumatological Surgery Department of the Reims University Hospital or the Godinot Institute * Patient with osteosarcoma or chondrosarcoma to be operated on regardless of stage. * Patient agreeing to participate in the study (informed consent form) * Patient fluent in French * Patient affiliated with a social security regimen Exclusion Criteria: * Patient having a medical history that may compromise the protocol (psychiatric, medical or pharmacological disorders such as the use of anti-inflammatory drugs, or any compound that may alter or modify the inflammatory reaction in the week preceding the protocol). * Pregnant or breastfeeding women * Patient with eating disorders (anorexia, bulimia, overeating) * Patient protected by law (guardianship, curatorship, hospitalized without their consent and not protected by law, deprived of liberty)
Where this trial is running
Reims
- Université de Reims Champagne-Ardenne — Reims, France (Recruiting)
Study contacts
- Principal investigator: Christophe MESA — Université de Reims Champagne-Ardenne - CHU de Reims
- Study coordinator: Christophe MESA
- Email: cmensa@chu-reims.fr
- Phone: 03 26 78 77 51
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.