Investigating mitochondrial dysfunction in schizophrenia patients treated with atypical antipsychotics

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the impact of atypical antipsychotic medications, specifically aripiprazole and risperidone, on mitochondrial function in patients diagnosed with schizophrenia. It focuses on treatment-naive individuals or those who have not taken antipsychotic drugs for at least four weeks prior to recruitment. The research will assess mitochondrial respiratory chain complex I activity to understand its role in the pathophysiology of schizophrenia and the effects of these medications. The study is conducted at the All India Institute of Medical Sciences in Bhubaneswar, Odisha.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients meeting the DSM-5 criteria for diagnosis of schizophrenia.
* Treatment naıv̈ e patients or patients who had not taken any antipsychotic drugs for at least 4 weeks before recruitment.
* Patients of either sex between the ages of 18 and 60 years.
* Legally authorized representative (LAR) of patients consenting to participate in the study by signing the informed consent form.

Exclusion Criteria:

* Patients diagnosed with other psychiatric disorders including schizoaffective disorder or schizophrenia with somatoform disorders.
* Highly agitated patients who need immediate indoor-based treatment.
* Patients with known mitochondrial disorders (MELAS, LHON, Leigh syndrome, KearnsSayre syndrome, MERRF etc.)
* Patients with history of comorbidities like cardiovascular, renal, hepatic, neurological, respiratory or endocrinal diseases or malignancies.
* Patients with history of substance abuse.
* Pregnant or lactating mothers.

Where it's running

• All India Institute of Medical Sciences (AIIMS)
  Bhubaneswar, Odisha, India Recruiting

Study contacts

• Study coordinator: Rituparna Maiti, MD
• Email: pharm_rituparna@aiimsbhubaneswar.edu.in
• Phone: 9438884191

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.