Investigating mental health in first-time pregnant women

Maternal Well-being in the Perinatal Period: a Prospective Observational Study

Observational IRCCS San Raffaele · NCT06473935

This study looks at the mental health of first-time pregnant women during their last trimester and the year and a half after childbirth to see how they cope with feelings like anxiety and depression, and to understand their needs for support.

Quick facts

Study typeObservational
Enrollment134 (estimated)
SexFemale
SponsorIRCCS San Raffaele Academic / other
Locations1 site (Milan)
Trial IDNCT06473935 on ClinicalTrials.gov

What this trial studies

This observational study aims to assess the mental health status of women experiencing their first pregnancy, focusing on anxiety, depression, loneliness, and defense mechanisms during the last trimester and the 18 months following childbirth. It will analyze the psychological adaptation of these women, exploring the bond with their child and differences between those who conceived naturally and through assisted reproductive technology. Additionally, qualitative methods such as interviews and focus groups will be employed to identify unmet needs and preferences for support interventions during the perinatal period.

Who should consider this trial

Good fit: Ideal candidates are women aged 18 and older who are experiencing their first pregnancy and are in the last trimester of gestation.

Not a fit: Patients who are not first-time mothers or are not in the last trimester of pregnancy will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved mental health support and interventions for first-time mothers during and after pregnancy.

How similar studies have performed: Other studies have shown success in exploring mental health during the perinatal period, making this approach relevant and potentially impactful.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age 18 years or older
* Adequate understanding of the Italian language
* Willingness to participate in the study, expressed through the signing of the information sheet, consent declaration, and privacy statement
* Women experiencing their first pregnancy
* Women in the last trimester of gestation (28th-35th week of gestation) who will be followed for 18 months after childbirth

Exclusion Criteria:

* Age under 18 years old
* Women who are not able to understand the Italian language
* Absence of the willingness to participate in the study, expressed through the signing of the information sheet, consent declaration, and privacy statement
* Women who are not experiencing their first pregnancy
* Women who are not in the last trimester of gestation (28th-35th week of gestation)

Where this trial is running

Milan

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Perinatal DepressionAnxietyLonelinessMother-Child Relations
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.