Investigating menstrual blood proteins in women with endometriosis
Proteomic Profile in Women With Endometriosis (PROTEO-ENDO) Study
This study is testing if proteins found in menstrual blood can help identify endometriosis in women compared to those who are healthy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 66 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT06214260 on ClinicalTrials.gov |
What this trial studies
This observational study aims to analyze the proteomic profile of menstrual blood in women diagnosed with endometriosis compared to healthy controls. A total of 66 women will be recruited, with 33 having endometriosis and 33 healthy participants. The study will explore differentially expressed proteins across various stages and subtypes of endometriosis to identify potential non-invasive diagnostic biomarkers. The goal is to enhance understanding of the disease's pathophysiology and improve diagnostic methods.
Who should consider this trial
Good fit: Ideal candidates include women aged 18-45 with a histologically confirmed diagnosis of endometriosis or healthy women in the same age range with no history of endometriosis-related symptoms.
Not a fit: Patients with a history of malignancy, autoimmune diseases, or those currently undergoing hormonal treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to the development of non-invasive diagnostic biomarkers for endometriosis, facilitating earlier and more accurate diagnosis.
How similar studies have performed: While there have been various studies exploring biomarkers for endometriosis, this specific approach focusing on menstrual blood proteomics is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Endometriosis group. are women aged 18-45 years old Laparoscopy with histologically confirmed diagnosis of endometriosis * Healthy group are women between 18-45 years old self reported no known history of medical \& surgical diseases and no any sign of endometriosis related symptoms Exclusion Criteria: Endometriosis group * Hormonal treatment in the past three months before surgery, * Previous and current malignancy * Having history of autoimmune disease * Having previous surgery due to endometriosis * Pelvic inflammatory disease (PID) * Lactating/breastfeeding women * Adenomyosis * Polycystic ovarian syndrome (PCOS) * History of or currently on traditional Chinese medicine - Healthy group * Hormonal treatment in the past three months before surgery, * Previous and current malignancy * Having history of autoimmune disease * Having previous surgery due to endometriosis * Pelvic inflammatory disease (PID) * Lactating/breastfeeding women * Adenomyosis * Polycystic ovarian syndrome (PCOS) * History of or currently on traditional Chinese medicine
Where this trial is running
Hong Kong
- The Chinese University of Hong Kong, Prince of Wales Hospital — Hong Kong, Hong Kong (Recruiting)
Study contacts
- Study coordinator: Chi Chiu Wang, MD, PhD
- Email: ccwang@cuhk.edu.hk
- Phone: (852) 35054267
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.