Investigating mast cells and their enzymes in COPD patients
The Role of Mast Cells and Its Proteases in Chronic Obstructive Pulmonary Disease
This study is testing how certain enzymes from mast cells in the airways of people with COPD might affect their symptoms and flare-ups.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 20 Years to 70 Years |
| Sex | All |
| Sponsor | Voronezh N.N. Burdenko State Medical Academy Academic / other |
| Locations | 1 site (Voronezh) |
| Trial ID | NCT06392334 on ClinicalTrials.gov |
What this trial studies
This study focuses on analyzing the role of mast cell proteases, specifically chymase and tryptase, in the tissues of small and large airways in patients with Chronic Obstructive Pulmonary Disease (COPD). By conducting biopsies, researchers aim to understand how these enzymes contribute to COPD exacerbations. The findings could provide insights into the underlying mechanisms of the disease and potential therapeutic targets.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with COPD.
Not a fit: Patients with other lung diseases, tumors, or those who are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for managing COPD exacerbations.
How similar studies have performed: While the specific focus on mast cell proteases in COPD is relatively novel, similar studies have explored the role of inflammatory mediators in respiratory diseases with varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: - COPD patients Exclusion Criteria: Other lung diseases, tumors, pregnancy -
Where this trial is running
Voronezh
- Voronezh State Medical University — Voronezh, Russian Federation (Recruiting)
Study contacts
- Study coordinator: Yanina Shkatova
- Email: yankashkat@gmail.com
- Phone: 89611875800
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.