Investigating lipoproteins in patients with ischemic stroke
AtheroGEnic LipoprotEinS in Ischemic Stroke: The AGELESS Study
This study is trying to see if certain fat proteins in the blood are linked to the risk of having a stroke in people with blocked carotid arteries.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Basel, Switzerland Academic / other |
| Locations | 2 sites (Basel and 1 other locations) |
| Trial ID | NCT05090878 on ClinicalTrials.gov |
What this trial studies
This observational cohort study aims to analyze the relationship between apolipoprotein B (apoB) levels, lipoprotein(a) (Lp(a)) levels, and intraplaque hemorrhage (IPH) in patients with carotid artery atherosclerosis. It will compare patients with and without IPH to assess cardiovascular risk factors and evaluate the risk of first-ever ischemic stroke in relation to these lipoprotein levels. The study will utilize magnetic resonance imaging to assess carotid plaque and follow patients for at least one year to monitor outcomes.
Who should consider this trial
Good fit: Ideal candidates include patients with atherosclerotic carotid stenosis between 30-99% who can undergo MRI and provide informed consent.
Not a fit: Patients with carotid stenosis due to non-atherosclerotic causes or those who cannot undergo MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of stroke risk factors and improve prevention strategies for patients with carotid artery atherosclerosis.
How similar studies have performed: Other studies have shown associations between lipoprotein levels and stroke risk, suggesting that this approach is supported by existing research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Atherosclerotic carotid stenosis, North American Symptomatic Trial Collaborators (NASCET) method 30-99% * Ability to undergo a neck MR for carotid plaque imaging * Ability to undergo a follow-up of at least 1-year * For the prospective, longitudinal part: Hemispheric ischemic stroke or retinal ischemia ipsilateral to the carotid stenosis, with symptom onset within 24 hours (these patients will be followed-up for recurrent ischemic stroke) Exclusion Criteria: * Carotid stenosis due to causes other than atherosclerosis (e.g. carotid dissection or post-actinic) * Contraindication to MRI * Lack of informed consent
Where this trial is running
Basel and 1 other locations
- University Hospital Basel, Department of Neurology/Stroke Center — Basel, Switzerland (Recruiting)
- University Hospital Zürich — Zürich, Switzerland (Not_yet_recruiting)
Study contacts
- Principal investigator: Gian Marco De Marchis, PD Dr. med. — Department of Neurology/Stroke Center; University Hospital Basel
- Study coordinator: Gian Marco De Marchis, PD Dr. med.
- Email: gian.demarchis@usb.ch
- Phone: +41 61 265 25 25
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.