Investigating immune responses in viral pneumonia and ARDS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on understanding the role of Mucosal Associated Invariant T (MAIT) cells in patients suffering from viral pneumonia and Acute Respiratory Distress Syndrome (ARDS). The study aims to dissect the immunopathology of ARDS, particularly in cases related to SARS-CoV-2 and influenza A virus, to identify potential endotypes that could benefit from targeted therapies. By analyzing the activation mechanisms and functions of MAIT cells, the researchers hope to provide insights that could lead to new precision-medicine approaches for treating ARDS. Patients admitted to critical care units for specific conditions will be monitored to gather data on immune responses and tissue repair processes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Patients admitted to critical care (Intensive Care Unit, Continuous Monitoring Unit, Intensive Care Unit) at the CHRU de Tours
* Patients admitted to critical care for one of the following reasons:

  * Acute community-acquired pulmonary infection (pneumonia),
  * Severe acute pancreatitis, with onset of ARDS criteria less than 48 hours ago,
  * Severe isolated head injury requiring invasive mechanical ventilation,
  * Severe burn defined by a burned surface area exceeding 20% and/or deep lesions exceeding 3% of the total body surface area, with the onset of ARDS criteria less than 48 hours ago,
  * Patient admitted to Intensive Care Medicine, requiring invasive mechanical ventilation,
  * Patient admitted to cardiac surgery for scheduled surgery for valve replacement and/or coronary artery bypass grafting, with inclusion the day before surgery,

Non-inclusion criteria :

* Patients with severe immunosuppression (impairing the ability to analyse the immune response, particularly T lymphocytes): active haematological malignancy, solid organ transplantation or bone marrow transplantation, systemic immunosuppressive treatment, ongoing chemotherapy (including immune checkpoint inhibitors).
* Person who has objected to data processing
* Patient under guardianship or curatorship

Where it's running

• University hospital
  Tours, France Recruiting

Study contacts

• Study coordinator: Youenn JOUAN, Dr
• Email: youenn.jouan@gmail.com
• Phone: 0247474038

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Optimal corticosteroid dosing for ARDS: short vs. prolonged therapy

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• Dexamethasone for sepsis-related ARDS in adults on ventilatory support

  This trial tests whether dexamethasone can help adults with sepsis-associated ARDS on ventilators recover better compared to placebo.

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• NIRS for EDResp: Which first helps hypoxemic adults best?

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• Sodium bicarbonate with bedside electrical impedance tomography to map lung blood flow in ventilated adults

  This project will try whether a small sodium bicarbonate injection combined with bedside electrical impedance tomography can map lung blood flow in adults on mechanical ventilation, compared with hypertonic saline.

  Recruiting First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui · NCT07542366

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.