Investigating how platelets contribute to complications from blood clots
The Role of Platelet TLRs in Platelet Activation During VTE
This study is trying to understand how platelets affect complications from blood clots in patients with venous thromboembolism to help improve their treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne Academic / other |
| Locations | 1 site (Saint-Étienne) |
| Trial ID | NCT06257290 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on understanding the role of platelets in the activation process during venous thromboembolism (VTE). It aims to explore the mechanisms behind post-thrombotic syndrome and post-pulmonary embolism syndrome, which are common complications following VTE. By analyzing blood samples from patients diagnosed with VTE within 72 hours, the study seeks to uncover the relationship between platelets, inflammation, and thrombosis. The findings could provide insights into better management strategies for patients suffering from these sequelae.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who have been diagnosed with VTE or proximal deep vein thrombosis within the last 72 hours.
Not a fit: Patients with a diagnosis of VTE older than 72 hours or those on antiplatelet agents or NSAIDs may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for patients suffering from complications related to venous thromboembolism.
How similar studies have performed: While the role of platelets in thrombosis is well-established, the specific focus on their contribution to VTE sequelae is relatively novel and has not been extensively tested in previous studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients diagnosed with Venous ThromboEmbolic (VTE) / Proximal Deep vein thrombosis (DVT) of the lower limb and/or pulmonary embolism ≤ 72heures * Patients are 18 years of age or older at diagnosis. * Patients received informed written consent * Patients benefiting from social security coverage Exclusion Criteria: * Diagnosis of Venous ThromboEmbolic (VTE) more than 72 hours old * Isolated sub-segmental pulmonary embolism * Patients on antiplatelet agents * Patients on non-steroidal anti-inflammatory drugs (NSAIDs) * Life expectancy \> 3 months
Where this trial is running
Saint-Étienne
- Chu St-Etienne — Saint-Étienne, France (Recruiting)
Study contacts
- Study coordinator: Laurent BERTOLETTI, MD PhD
- Email: laurent.bertoletti@gmail.com
- Phone: 477829121
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.