Investigating how oxytocin works during cesarean deliveries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to understand the pharmacokinetics and pharmacodynamics of oxytocin in parturients undergoing non-emergent cesarean deliveries. Participants will receive a bolus of deuterated oxytocin followed by a standard oxytocin infusion after the delivery of the fetus. Blood samples will be collected at various time points to analyze the concentration of oxytocin and its effect on uterine contraction. The study will help clarify how oxytocin functions in preventing uterine atony, a condition affecting many postpartum women.

Why it matters

Who can join: the full rules

Inclusion Criteria

* 18-50 years old
* intrauterine pregnancy
* term (\>39 weeks gestation or 37-39 weeks gestation with fetal or maternal medical indication for delivery) pregnancy
* non-emergent (scheduled or unscheduled) cesarean delivery

Exclusion Criteria:

* allergy or contraindication to oxytocin
* inability to provide informed consent

Where it's running

• University of Chicago
  Chicago, Illinois, United States Recruiting
• Stanford University
  Stanford, California, United States Not yet recruiting

Study contacts

• Principal investigator: Naida M Cole, MD — University of Chicago
• Study coordinator: Naida M Cole, MD
• Email: nmcole@bsd.uchicago.edu
• Phone: 773-702-6700

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Myofascial release versus deep friction massage for C-section scar healing and abdominal recovery

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.