Investigating how nicotine affects behavior in users
Effects of Acute Nicotine Administration on Motivational Mechanisms
This study is trying to see how nicotine affects the way adult users react to rewards and punishments.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 21 Years and up |
| Sex | All |
| Sponsor | University of Southern California Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Trial ID | NCT06027723 on ClinicalTrials.gov |
What this trial studies
This study examines the impact of acute nicotine administration on Pavlovian bias among adult nicotine users. By utilizing a within-subjects, repeated-measured design, the research aims to determine whether nicotine influences individuals' tendencies to approach rewarding cues and withdraw from punishments. The study will recruit forty participants from the University of Southern California community, focusing on those who have used nicotine at least monthly over the past three months. Insights gained from this research could enhance understanding of nicotine addiction and impulsive behavior patterns.
Who should consider this trial
Good fit: Ideal candidates are adults aged 21 and older who are current nicotine users and willing to abstain from nicotine for at least 10 hours prior to lab visits.
Not a fit: Patients who are currently pregnant, planning to become pregnant, or breastfeeding will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into the mechanisms of nicotine addiction and inform strategies for quitting.
How similar studies have performed: Previous studies have indicated that Pavlovian bias is a universal phenomenon, suggesting that this approach may yield meaningful insights into nicotine addiction.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * At least 21 years old * Current nicotine user (at least monthly use over the past 3 months) * Reported willingness to abstain from all nicotine for at least 10 hours prior to the two lab visits * English Language Competency Exclusion Criteria: - Currently pregnant, planning to become pregnant, or breastfeeding
Where this trial is running
Los Angeles, California
- University of Southern California — Los Angeles, California, United States (Recruiting)
Study contacts
- Study coordinator: Veronika Sidorova
- Email: sidorova@usc.edu
- Phone: 424-438-8597
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.