Investigating how carbonated water affects blood pressure when standing
The Effect of Water Carbonation on Orthostatic Tolerance
This study is testing if drinking carbonated water can help healthy people maintain their blood pressure better when standing up.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 19 Years to 50 Years |
| Sex | All |
| Sponsor | Simon Fraser University Academic / other |
| Locations | 1 site (Burnaby, British Columbia) |
| Trial ID | NCT05621460 on ClinicalTrials.gov |
What this trial studies
This investigation aims to determine if drinking carbonated water can enhance orthostatic tolerance in healthy volunteers. Orthostatic tolerance is the ability to maintain blood pressure while standing, which can be compromised in some individuals, leading to dizziness or fainting. The study will involve 25 volunteers undergoing a tilt test to measure their cardiovascular response and time to presyncope after consuming carbonated and non-carbonated water. The hypothesis is that carbonated water may provoke gastric distension, increasing sympathetic activity and thereby boosting blood pressure more than still water.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy, English-speaking adults without a history of cardiovascular or neurological diseases.
Not a fit: Patients with a history of recurrent fainting or those who are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into a simple dietary intervention to help prevent fainting episodes in susceptible individuals.
How similar studies have performed: While the specific effects of carbonated water on orthostatic tolerance are not well-studied, related interventions have shown promise in improving blood pressure responses in similar contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * healthy, English-speaking Exclusion Criteria: * pregnancy or suspected pregnancy, history of cardiovascular disease, history of neurological disease, history of recurrent fainting (≥ 2 episodes of fainting with loss of consciousness in the prior 6 months)
Where this trial is running
Burnaby, British Columbia
- Simon Fraser University — Burnaby, British Columbia, Canada (Recruiting)
Study contacts
- Principal investigator: Victoria E Claydon, PhD — Professor, Biomedical Physiology and Kinesiology
- Study coordinator: Victoria E Claydon, PhD
- Email: victoria_claydon@sfu.ca
- Phone: 7787828513
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.