Investigating how calcium affects carbetocin's ability to contract the uterus after cesarean delivery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the role of extracellular calcium in enhancing the contractility of the human myometrium when treated with carbetocin, a uterotonic agent used to prevent postpartum hemorrhage (PPH) during cesarean deliveries. By examining non-laboring women scheduled for cesarean sections, the research will assess how varying calcium levels influence uterine contractions in response to carbetocin. The findings could provide insights into optimizing PPH management, especially for women with comorbidities that increase their risk of bleeding. This is the first ex vivo study to investigate this relationship, potentially paving the way for improved treatment protocols.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* non-laboring women with gestational age between 37 to 41 weeks
* not exposed to exogenous oxytocin, scheduled for a primary or first repeat cesarean delivery under neuraxial anesthesia.

Exclusion criteria:

* patients requiring general anesthesia
* more than 1 previous cesarean delivery
* history of uterine atony
* emergency cesarean section in labor
* patients using medications that could affect myometrial contractility such as nifedipine, labetalol, or magnesium sulphate.
* patients with any condition of predisposing to uterine atony and postpartum hemorrhage, such as abnormal placentation, multiple gestation, severe preeclampsia, macrosomia, polyhydroamnios, large uterine fibroids, chorioamnionitis, previous history of postpartum bleeding.

Where it's running

• Mount Sinai Hospital
  Toronto, Ontario, Canada Recruiting

Study contacts

• Study coordinator: Mrinalini Balki, MD
• Email: mrinalini.balki@uhn.ca
• Phone: 416-586-480

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Carbetocin with calcium chloride to improve uterine contraction after elective cesarean

  This trial will test whether giving carbetocin together with calcium chloride helps the uterus stay contracted and reduces bleeding during scheduled cesarean deliveries at term.

  Recruiting Samuel Lunenfeld Research Institute, Mount Sinai Hospital · Toronto, Ontario · NCT07187544

• Using the Alma System to treat severe bleeding after childbirth

  This study is testing whether the Alma System can safely and effectively stop severe bleeding after childbirth in women who have experienced postpartum hemorrhage.

  Recruiting Phase 3 ResQ Medical Ltd · Brooklyn, New York and 1 other locations · NCT06646653

• Long-term outcomes after vacuum-induced tamponade for postpartum hemorrhage

  This study will look at women who had postpartum hemorrhage treated with vacuum-induced tamponade at a Zurich hospital to see how they fared over time, including future pregnancies and fertility.

  Recruiting University of Zurich · Zurich, Canton of Zurich · NCT07885072

• Calcium Gluconate After Birth to Reduce Blood Loss in Vaginal Delivery

  This study tests whether giving calcium gluconate right after the baby is born can help reduce blood loss for people having a vaginal delivery.

  Recruiting Rambam Health Care Campus · Haifa · NCT07714902

• Carbetocin Alone vs Carbetocin Plus Oxytocin After Elective Cesarean Delivery

  This study tests whether giving carbetocin by itself after an elective cesarean is just as good as adding a supplemental oxytocin infusion.

  Recruiting Phase 4 Mansoura University · Buraidah, Al-Qassim Region · NCT07636421

• Simulation-based postpartum hemorrhage training to boost anesthesiology team performance

  Senior anesthesiology residents will try a high-fidelity simulation program for postpartum hemorrhage to see if it improves how their teams perform during obstetric emergencies.

  Recruiting Hacettepe University · Ankara, Ankara · NCT07519252

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.