Investigating heart function's role in weaning from mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the relationship between left and right ventricular systolic function and the occurrence of weaning-induced pulmonary edema (WIPO) in critically ill patients undergoing mechanical ventilation. It focuses on patients who have been on invasive mechanical ventilation for over 48 hours and are deemed suitable for a spontaneous breathing trial. By utilizing echocardiography, the study will assess the systolic function of the heart to determine its impact on weaning success and the risk of pulmonary edema. The findings could provide insights into improving weaning strategies and patient outcomes in intensive care settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Invasive mechanical ventilation for more than 48 hours
2. Patients indicated, according to intensivists, for carrying out a spontaneous breathing trial weaning test, based on the presence of all of the following criteria:

   1. SpO2\> 90% with FiO2 ≤40% and PEEP ≤5 cmH2O
   2. Cough effectiveness on tracheal aspirations
   3. Lack of hemodynamic instability and of disorders of consciousness
3. Patients at high risk of weaning-induced pulmonary edema (WIPO), defined by one or more of the following criteria:

   1. Obesity, defined by a body mass index\> 30 kg/m²
   2. Chronic obstructive pulmonary disease
   3. Chronic heart disease

Exclusion Criteria:

1. Age \<18 years and pregnant women
2. Patients with a decision of not to resuscitate
3. Poor echogenicity
4. Severe mitral valve disease (leakage and/or stenosis, bioprosthesis)
5. Patients with pacemaker
6. Tracheostomy
7. Chronic neuromuscular or neurodegenerative diseases

Where it's running

• CHU de Dijon
  Dijon, France Recruiting
• CHU de NICE
  Nice, France Recruiting
• Hôpital Cochin
  Paris, France Recruiting

Study contacts

• Study coordinator: Mathieu JOZWIAK, MD, PhD
• Email: jozwiak.m@chu-nice.fr
• Phone: 33492035510

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.