Investigating heart failure in cirrhosis patients after TIPS procedure
Incidence and Predictors of Post-TIPS (Transjugular Intrahepatic Portosystemic Shunt (TIPS) Heart Failure in Patients With Cirrhosis
West China Hospital · NCT05596253
This study is trying to see how often heart failure happens in liver cirrhosis patients after they have a TIPS procedure and what factors might affect their heart health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | West China Hospital (other) |
| Locations | 1 site (Chengdu, Sichuan) |
| Trial ID | NCT05596253 on ClinicalTrials.gov |
What this trial studies
This observational study aims to prospectively assess the incidence of heart failure in patients with liver cirrhosis who have undergone a transjugular intrahepatic portosystemic shunt (TIPS). It will analyze the predictors and modifications of cardiac function in these patients, considering the hyperdynamic circulation often seen in cirrhosis. The study seeks to fill a gap in existing research regarding the cardiac implications of TIPS, which is commonly used to manage complications of cirrhosis such as refractory ascites and variceal bleeding. By understanding these dynamics, the study hopes to provide insights into managing cardiac health in this patient population.
Who should consider this trial
Good fit: Ideal candidates for this study are patients diagnosed with cirrhosis who have successfully undergone the TIPS procedure.
Not a fit: Patients with non-cirrhotic portal hypertension, previous TIPS, or existing heart failure may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved monitoring and management strategies for heart failure in cirrhosis patients post-TIPS.
How similar studies have performed: There is limited existing research specifically addressing heart failure incidence post-TIPS in cirrhosis patients, making this study a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Cirrhosis 2. TIPS is placed successfully 3. Agree to participate in the trial Exclusion Criteria: 1. Non-cirrhotic portal hypertension 2. Previous TIPS or surgical shunt 3. Medium to severe pulmonary hypertension 4. Heart failure 5. End-stage renal disease requiring hemodialysis 6. Respiratory failure 7. Malignancies with a life expectancy of less than 6 months
Where this trial is running
Chengdu, Sichuan
- West China Hospital of Sichuan University — Chengdu, Sichuan, China (RECRUITING)
Study contacts
- Principal investigator: xuefeng luo — Sichuan University
- Study coordinator: Xuefeng Luo
- Email: luo_xuefeng@yeah.net
- Phone: +86 18980606826
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Liver Cirrhosis, Transjugular Intrahepatic Portosystemic Shunt, Heart Failure