Investigating gut microbiota in patients with acute stroke
Gut Microbiota in Acute Stroke Patients
This study is trying to see if the bacteria in the gut of people who have had a stroke can help us understand their recovery and disability over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT03934021 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the role of gut microbiota in patients who have experienced an acute ischemic stroke. Participants will be recruited from the Prince of Wales Hospital and will provide stool samples for analysis. Their neurological and radiological outcomes will be assessed at 3 and 6 months post-stroke to identify any correlations between microbiota composition and clinical outcomes. The study will also evaluate the degree of disability and imaging findings to better understand stroke mechanisms.
Who should consider this trial
Good fit: Ideal candidates are Chinese adults aged 18 and above who have been diagnosed with acute ischemic stroke.
Not a fit: Patients with alternative diagnoses, gastrointestinal infections, or recent antibiotic use may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new insights into the relationship between gut health and stroke recovery, potentially improving patient outcomes.
How similar studies have performed: While the role of gut microbiota in various health conditions is being explored, this specific approach in acute stroke patients is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Diagnosed as acute ischaemic stroke 2. Aged 18 or above Chinese 3. Radiological evidence of acute ischaemic stroke by Computed tomography (CT) or magnetic resonance imaging (MRI) brain. Exclusion Criteria: 1. Patient with symptoms and signs suggestive of alternative diagnoses, 2. Evidence of intracerebral haemorrhage, 3. Absence of DWI evidence of acute ischaemic infarct, 4. Pregnancy, 5. Evidence of gastrointestinal infection/ inflammation/ obstruction 6. History of partial or total resection of small or large bowel, as well as gut re-anastomosis, 7. Use of antibiotics within 2 weeks prior to symptoms onset, 8. Gastrointestinal malignancy 9. Any hospitalization within 3 months before recruitment 10. Institutionalized patients
Where this trial is running
Hong Kong
- Chinese University of Hong Kong — Hong Kong, Hong Kong (Recruiting)
Study contacts
- Principal investigator: Yiu Ming Bonaventure IP, MRCP — Chinese University of Hong Kong
- Study coordinator: Yiu Ming Bonaventure IP, MRCP
- Email: iym984@ha.org.hk
- Phone: 852-35053856
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.