Investigating genetic factors in young patients with coronary artery disease
A Multi-omics Study of Patients With Premature Coronary Artery Disease in the Absence of Common Risk Factors
The First Affiliated Hospital with Nanjing Medical University · NCT06362278
This study is trying to find out how genetics and other factors affect young people with coronary artery disease to help prevent it better in the future.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 160 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | The First Affiliated Hospital with Nanjing Medical University (other) |
| Locations | 3 sites (Nanjing, Jiangsu and 2 other locations) |
| Trial ID | NCT06362278 on ClinicalTrials.gov |
What this trial studies
This observational clinical trial aims to explore the genetic risk factors and metabolic profiles of patients with premature coronary artery disease (CAD) using a multi-omics approach. The study will involve in-patients from three major hospitals in China, focusing on those diagnosed with obstructive CAD at a young age. By analyzing genetic data and other non-traditional risk factors, the research seeks to enhance primary prevention strategies for this specific subgroup of CAD patients. The findings could provide insights into the etiology and pathogenesis of CAD, which remains a leading cause of mortality worldwide.
Who should consider this trial
Good fit: Ideal candidates include young patients diagnosed with obstructive CAD, specifically males under 45 and females under 55.
Not a fit: Patients without obstructive CAD or those older than the specified age limits may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prevention strategies for young patients at risk of coronary artery disease.
How similar studies have performed: While there have been studies on CAD risk factors, this multi-omics approach in a premature CAD population is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria for cases: 1. In-patients from cardiology department of either following 3 hospitals: a) The First Affiliated Hospital of Nanjing Medical University; b) Qilu Hospital of Shandong University; c) The Second Affiliated Hospital Zhejiang University School of Medicine 2. Confirmed diagnosis of Obstructive CAD (≥50% diameter stenosis in a major epicardial vessel) through coronary angiography 3. Age of the patient when Obstructive CAD was for the first time diagnosed should be no more than 45 years old for the male and 55 years old for the female. Inclusion Criteria for controls: 1. In-patients from cardiology department of either following 3 hospitals: a) The First Affiliated Hospital of Nanjing Medical University; b) Qilu Hospital of Shandong University; c) The Second Affiliated Hospital Zhejiang University School of Medicine 2. Coronary artery stenosis was ruled out through either coronary angiography or coronary CTA. Exclusion Criteria for both cases and controls: 1. Patients with hypertension (grade 1-3) 2. Patients with type 1 or type 2 diabetes mellitus 3. BMI \>28.0 Kg/m\^2 4. Patients with non-ideal blood lipids level on admission(defined as either LDL-C≥2.6mmol/L OR non-HDL cholesterol≥3.4mmol/L OR Lipoprotein(a) ≥300mg/L) 5. Smoker (Smoking for more than 6 consecutive or cumulative months in a lifetime, whether quit smoking or not) 6. Patients with hyperuricemia or gout 7. eGFR\<60 ml/min·1.73m\^2 8. Patients with structural heart diseases, inherited cardiomyopathies \& arrhythmias 9. Other reasons a participant considered unsuitable for inclusion by researchers.
Where this trial is running
Nanjing, Jiangsu and 2 other locations
- First Affiliated Hospital of Nanjing Medical University — Nanjing, Jiangsu, China (RECRUITING)
- Qilu Hospital of Shangdong University — Jinan, Shandong, China (ACTIVE_NOT_RECRUITING)
- The Second Affiliated Hospital of Zhejiang University Medical College — Hangzhou, Zhejiang, China (ACTIVE_NOT_RECRUITING)
Study contacts
- Principal investigator: Chunjian Li, PHD — The First Affiliated Hospital with Nanjing Medical University
- Study coordinator: Chunjian Li, PHD
- Email: lijay@njmu.edu.cn
- Phone: +86 13701465229
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Coronary Artery Disease, coronary artery disease, multi-omics, premature