Investigating genetic factors in cardiovascular and immune-related diseases using healthy volunteers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the genetic factors influencing cardiovascular diseases by examining healthy volunteers who have been genotyped. Researchers will focus on two specific genes, SWAP70 and GMPR, which are believed to play roles in immune response and red blood cell formation, respectively. Participants will undergo a single study visit where they will complete questionnaires and undergo various health measurements, including blood pressure and blood samples. The goal is to identify molecular mechanisms linked to genetic variants associated with cardiovascular and immune-related traits.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Have consented to be part of the NIHR BioResource;
* Are aged 18 years and above;
* Have given written informed consent to participate in the GENBIO study;
* Are carriers or non-carriers of the candidate functional genetic variant(s) of interest.

Exclusion Criteria:

Have a chronic disease, including cardiovascular diseases, autoimmune diseases and cancer.

Additional exclusion criteria to be applied at the discretion/opinion of the CI/collaborator, based on the population of available volunteers for recall and the genetic variant of interest (e.g. allele frequency):

* Have a biological first-degree relatives (parents, brothers, sisters or children) who are suffering or have suffered from a disease/condition in the opinion of the CI/collaborator that, from a genetic standpoint, may affect the study validity;
* Are current regular smokers. Regular ex-smokers are suitable if they stopped smoking \>10 years ago (regular defined as 1 pack year in both instances);
* Have ≥3 alcoholic drinks per day;
* Have a diagnosis of hypertension, or history of consistently high blood pressure readings, e.g. \>140/90 mmHg;
* Have a diagnosis of hypercholesterolemia, or history of consistently high cholesterol levels, e.g. total cholesterol level \>6 mmol/l;
* Are obese (i.e. BMI \>30);
* Are unwilling to fast and not to consume products containing alcohol or caffeine 12 hours prior to procedures.

Where it's running

• Department of Public Health and Primary Care
  Cambridge, Cambridgeshire, United Kingdom Recruiting

Study contacts

• Principal investigator: Dirk Paul, PhD — University of Cambridge
• Study coordinator: Dirk Paul, PhD
• Email: dsp35@medschl.cam.ac.uk
• Phone: 01223 761918

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.