Investigating genetic and cognitive factors that affect aphasia treatment response
Laying the Groundwork for Personalized Medicine in Aphasia Therapy: Genetic and Cognitive Predictors of Restorative Treatment Response
NA · Ohio State University · NCT05179538
This study is trying to see how genetics and memory skills affect how well people with aphasia respond to therapy after a stroke.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Ohio State University (other) |
| Locations | 1 site (Columbus, Ohio) |
| Trial ID | NCT05179538 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the relationship between genetic factors and cognitive abilities in predicting how individuals with aphasia respond to therapy after a stroke. Specifically, it will examine the influence of two genes, ApoE and BDNF, along with working memory skills, on treatment outcomes for patients experiencing word-retrieval difficulties. By identifying these predictors, the study seeks to enhance treatment planning and improve patient-specific approaches to aphasia therapy. The ultimate goal is to maximize the effectiveness of interventions for individuals with chronic post-stroke aphasia.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals who are at least six months post-onset of a single left-hemisphere stroke and have chronic aphasia with anomia.
Not a fit: Patients with severe motor speech disorders, severe auditory comprehension deficits, or other significant cognitive impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more personalized and effective aphasia treatments, improving recovery outcomes for patients.
How similar studies have performed: While there is limited research specifically linking genetics to aphasia treatment response, similar studies in other areas of rehabilitation have shown promise in using genetic and cognitive factors to tailor therapies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * At least six months post-onset of a single left-hemisphere stroke * Chronic aphasia * Anomia (word-retrieval deficits) * Native English Speaker. Exclusion Criteria: * Severe motor speech disorders * Severe auditory comprehension deficits * Severe depression. * Diffuse injury or disease of the brain * Uncorrected vision or hearing difficulties * Contraindications for MRI (e.g. cardiac pacemaker, ferrous metal implants, claustrophobia, pregnancy).
Where this trial is running
Columbus, Ohio
- The Ohio State University — Columbus, Ohio, United States (RECRUITING)
Study contacts
- Principal investigator: Stacy M Harnish, PhD — Ohio State University
- Study coordinator: Stacy Harnish, PhD, CCC-SLP
- Email: aphasialab@osu.edu
- Phone: 6146881471
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Aphasia