Investigating frailty and muscle relaxant effects in gynecologic cancer surgery
Incidence of Residual Neuromuscular Blockade in Patients With Frailty Undergoing Gynecologic Cancer Surgery
This study is testing how frailty affects the way patients process anesthesia and their recovery after gynecologic cancer surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 622 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Mahidol University Academic / other |
| Locations | 1 site (Bangkok, Bangkok) |
| Trial ID | NCT06216002 on ClinicalTrials.gov |
What this trial studies
This study examines the relationship between frailty and the incidence of residual neuromuscular blockade in patients undergoing oncologic gynecological surgery. It aims to assess how frailty influences the metabolism of anesthetic agents and the prevalence of postoperative complications. By utilizing a train of four nerve stimulator, the research will gather data on frailty and its impact on surgical outcomes. The findings could provide insights into improving perioperative care for frail patients in gynecologic oncology.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older who are scheduled for elective gynecologic-oncology surgery.
Not a fit: Patients who are unable to communicate in Thai, have preexisting neuromuscular diseases, or have wrist conditions affecting nerve stimulation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for frail patients undergoing gynecologic surgery, potentially reducing postoperative complications and mortality.
How similar studies have performed: While this specific correlation has not been previously studied, related research has indicated significant associations between frailty and surgical outcomes in other contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \>,= 18 years * Patients undergoing elective gynecologic-oncology surgery Exclusion Criteria: * Unable to communicate Thai * Unable to understand the questionnaire * Preexisting neuromuscular disease * Preexisting disease involved wrist that may affect the nerve stimulator examination
Where this trial is running
Bangkok, Bangkok
- Anesthesiology department, Siriraj hospital, Mahidol University — Bangkok, Bangkok, Thailand (Recruiting)
Study contacts
- Principal investigator: Jitsupa Nithiuthai, M.D. — Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University
- Study coordinator: Patchareya Nivatpumin, M.D.
- Email: patchareya.niv@mahidol.ac.th
- Phone: +66896662187
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.