Investigating fluid and vasopressor therapy in critically ill patients on invasive ventilation
Practice of Fluid Therapy in Critically Ill Invasively Ventilated Patients (PRoFLUID)--an International Multicenter Observational Cohort Study
This study looks at how doctors use fluids and medications to support critically ill patients on ventilators to see how these treatments affect their recovery and survival in different countries.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2500 (estimated) |
| Ages | 16 Years and up |
| Sex | All |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Academic / other |
| Locations | 1 site (Amsterdam, Noord-Holland) |
| Trial ID | NCT05968066 on ClinicalTrials.gov |
What this trial studies
This worldwide observational study aims to explore the current practices of fluid and vasopressor therapy in critically ill patients who are invasively ventilated. It will gather detailed data from intensive care units regarding the therapies prescribed and their associations with clinical outcomes, such as duration of ventilation, length of hospital stay, and mortality rates. The study will compare practices between low- and middle-income countries and high-income countries to identify variations in treatment approaches.
Who should consider this trial
Good fit: Ideal candidates for this study are critically ill patients who are receiving invasive ventilation for more than 24 hours.
Not a fit: Patients under the age of 16 or those transferred from another ICU while still on invasive ventilation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved guidelines for fluid and vasopressor therapy in critically ill patients, enhancing patient outcomes.
How similar studies have performed: Other studies have shown varying practices in critical care settings, but this specific observational approach to fluid and vasopressor therapy is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Admitted to a participating intensive care unit; * Receiving invasive ventilation; and * Duration of ventilation \> 24 hours. Exclusion Criteria: * Age \< 16 years; * Patients transferred under invasive ventilation from another intensive care unit.
Where this trial is running
Amsterdam, Noord-Holland
- Amsterdam UMC — Amsterdam, Noord-Holland, Netherlands (Recruiting)
Study contacts
- Principal investigator: Pieter R. Tuinman, MD — Amsterdam UMC, location VUmc
- Study coordinator: Siebe G. Blok, MD
- Email: siebeblok@gmail.com
- Phone: 020 566 9111
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.