Investigating flow-controlled ventilation during robot-assisted laparoscopic surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot trial aims to evaluate the safety and feasibility of flow-controlled ventilation (FCV) compared to pressure-controlled ventilation (PCV) in patients undergoing robot-assisted laparoscopic surgery. The study focuses on patients at increased risk for postoperative pulmonary complications (PPCs) and will assess the impact of FCV on lung-specific outcomes during and after surgery. By optimizing intraoperative ventilation strategies, the trial seeks to reduce the incidence of complications associated with mechanical ventilation. The findings will inform the design of a larger trial to test the efficacy of FCV in improving postoperative outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* undergoing elective robot-assisted laparoscopic surgery in supine or Trendelenburg position (either abdominal, urologic or gynecologic surgery);
* AND increased risk of PPCs according to the ARISCAT risk score (≥ 26 points);
* OR the combination of age \> 40 years, scheduled surgery lasting \> 2 hours and planned to receive an intra-arterial catheter for blood pressure monitoring during the surgery;
* aged ≥ 18 years; and
* able to give written informed consent to participate in the study and agree to comply with the study protocol prior to initiation of any study-mandated procedure and study intervention.

Exclusion Criteria:

* ideal body weight \< 40 kg;
* ASA Physical Status Classification System score IV - VI;
* previous enrolment into the current study;
* being the study investigator, his/her family members, employees and other dependent persons;
* if female and of childbearing potential, known pregnancy or a positive urine pregnancy test (confirmed by a positive serum pregnancy test), or lactating; or
* No informed consent

Where it's running

• Department of Anaesthesiology, Medical University Innsbruck
  Innsbruck, Tyrol, Austria Recruiting
• Department of Anesthesiology, Intensive Care and Pain Medicine, BG University Hospital Bergmannsheil, Ruhr-University Bochum, Germany
  Bochum, Germany, Germany Completed
• Department of Anaesthesiology, Rescue- and Pain Medicine Cantonal Hospital St. Gallen
  Sankt Gallen, Canton of St. Gallen, Switzerland Completed

Study contacts

• Principal investigator: Timur Yurttas, MD — Department of Anesthesiology, Rescue- and Painmedicine, Cantonal Hospital St. Gallen, Switzerland
• Study coordinator: Timur Yurttas, MD
• Email: proflow@kssg.ch
• Phone: +41714949158

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Automated ABPI for Peripheral Artery Disease: A Pilot Look at Two Devices

  This pilot checks if two automated ankle-brachial pressure index devices can reliably detect PAD across symptom levels and after bypass surgery, using patient and clinician feedback for practicality.

  Recruiting Hull University Teaching Hospitals NHS Trust · Hull · NCT07850349

• AI-powered personalized exercise plan for older adults using a wearable app

  A wearable-enabled, AI-driven exercise app is tested to see if it’s feasible and acceptable for adults 65+ and whether it can help increase activity, improve mood, and boost quality of life.

  Recruiting The University of Tennessee, Knoxville · Knoxville, Tennessee · NCT07768670

• Early breathing therapy just one hour after CABG extubation

  This trial tests whether starting respiratory physiotherapy one hour after extubation improves recovery for adults after elective CABG compared with starting on the first postoperative day.

  Recruiting Alma Mater Europaea - Slovenia · Zagreb · NCT07730034

• Timing of Recruitment Maneuver in Robotic Prostate Surgery

  This study tests whether doing a recruitment maneuver before or after CO2 insufflation during robotic prostate surgery helps prevent lung problems afterward.

  Recruiting Ankara University · Ankara · NCT07662642

• Behavioral program to help depressed nursing home residents see if it helps

  This study tests the InSTILL program to see if it is feasible, satisfactory, and helpful for residents of skilled nursing facilities who have depressive symptoms.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07655232

• Early pregnancy lifestyle patterns and glucose changes in a TOFFFY sub-study

  This study tests whether daily patterns like sleep, activity, and meal timing in early pregnancy affect glucose levels and the risk of gestational diabetes, using CGM and wearable data in pregnant women in Singapore.

  Recruiting KK Women's and Children's Hospital · Singapore, Singapore · NCT07534670

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.