Investigating fatigue mechanisms in fibromyalgia patients
Is Cortical Motor Neuron Dysfunction the Underlying Mechanism of Fatigue in Fibromyalgia?
This study is trying to see if problems with brain signals are causing fatigue in people with fibromyalgia and how things like cheering might affect their muscle responses.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 36 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | Female |
| Sponsor | Istanbul Physical Medicine Rehabilitation Training and Research Hospital Government |
| Locations | 1 site (İstanbul, Bahçelievler) |
| Trial ID | NCT06778681 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the role of cortical motor neuron dysfunction in the fatigue experienced by patients with fibromyalgia. Participants will undergo assessments including the Fatigue Severity Scale, grip strength measurement, and walking speed tests, followed by V-wave recordings to compare results between fibromyalgia patients and healthy controls. The study will utilize advanced data acquisition systems to analyze muscle force and EMG signals during specific contractions. The goal is to determine if fibromyalgia patients exhibit lower V-wave responses compared to healthy subjects and how external factors like cheering may influence these responses.
Who should consider this trial
Good fit: Ideal candidates are females aged 18-60 diagnosed with fibromyalgia according to the 2016 criteria.
Not a fit: Patients with conditions causing muscle and nerve dysfunction, or those with other diseases associated with fatigue symptoms, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to a better understanding of fatigue in fibromyalgia, potentially guiding new treatment strategies.
How similar studies have performed: While the specific approach of this study is novel, similar studies have explored fatigue mechanisms in fibromyalgia with varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosed with fibromyalgia according to acr 2016 criteria(for fibromyalgia group) * Being healthy(for control group) * 18-60 years old * Volunteering * Being female * Right hand dominant Exclusion Criteria: * Presence of scars, dermatitis, or similar conditions on the skin where surface EMG electrodes will be placed. * Diseases causing muscle and nerve dysfunction: myopathies, polyneuropathy, radiculopathy, peripheral nerve lesions such as entrapment neuropathies; central nervous system disorders such as stroke, amyotrophic lateral sclerosis, multiple sclerosis, and parkinsonism. * Hypertension and cardiac arrhythmias. * Other diseases with fatigue symptoms: cardiopulmonary diseases, hypothyroidism, polymyalgia rheumatica, major depression, bipolar disorder, chronic fatigue syndrome. * Epilepsy
Where this trial is running
İstanbul, Bahçelievler
- Istanbul Physical Medicine Rehabilitation Training & Research Hospital — İstanbul, Bahçelievler, Turkey (Recruiting)
Study contacts
- Study coordinator: Fuat O. Alayoğlu, M.D.
- Email: f.orhunalayoglu@gmail.com
- Phone: 5348431984
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.