Investigating factors related to intracranial aneurysms in China

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the epidemiological factors associated with the formation, progression, and rupture of intracranial aneurysms (IA) in the Chinese population. By utilizing large-scale electronic medical records from multiple high-volume stroke centers, the study will analyze various exposures and their potential links to IA incidence. Patients diagnosed with IA or excluded through advanced imaging techniques will be included, and their data will be processed using natural language processing to extract relevant exposures. The goal is to enhance understanding of risk factors and inform future prospective research.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. IA diagnosis (ruptured or unruptured) or exclusion by digital subtractive angiography (DSA) or by cranial computed tomography angiography (CTA) / magnetic resonance angiography (MRA);
2. Aged ≥ 18 and ≤ 18 years old;
3. With complete demographic data including age and sex;
4. With medical record archiving officially.

Exclusion Criteria:

1. Missing data of age, sex or hypertensive status;
2. Age \<18 or \>80 years;
3. Pregnancy;
4. With a history of intracranial arteriovenous malformation, Moyamoya, polycystic kidney disease, Ehlers-Danlos syndrome, Gronblad-Strandberg syndrome, or Marfan syndrome;
5. Suspicion for dissecting or mycotic aneurysms or aneurysm-like lesions that were indistinguishable from the infundibulum, fenestration, dilation, or atherosclerotic remodeling on structural imaging scans.

Where it's running

• Zhujiang Hospital
  Guangzhou, China Recruiting

Study contacts

• Study coordinator: Chuanzhi Duan, MD, PhD
• Email: doctor_duanzj@163.com
• Phone: 15622311746

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.