Investigating factors related to intracranial aneurysms in China
Epidemiological Insights Into the Formation, Progression, and Rupture of Aneurysms: A Retrospective, Multi-Center Hospital-Based Study in China
This study looks at what factors might cause or worsen brain aneurysms in people in China to help understand the risks better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30000 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Zhujiang Hospital Academic / other |
| Locations | 1 site (Guangzhou) |
| Trial ID | NCT06456814 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the epidemiological factors associated with the formation, progression, and rupture of intracranial aneurysms (IA) in the Chinese population. By utilizing large-scale electronic medical records from multiple high-volume stroke centers, the study will analyze various exposures and their potential links to IA incidence. Patients diagnosed with IA or excluded through advanced imaging techniques will be included, and their data will be processed using natural language processing to extract relevant exposures. The goal is to enhance understanding of risk factors and inform future prospective research.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 80 with a diagnosis of intracranial aneurysm or those who have been ruled out through imaging.
Not a fit: Patients with a history of specific vascular conditions or those outside the age range of 18 to 80 may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved screening and prevention strategies for intracranial aneurysms, potentially reducing the incidence of fatal ruptures.
How similar studies have performed: While this study employs a novel approach by integrating multi-modal data from various centers, similar studies have shown success in identifying risk factors for aneurysms.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. IA diagnosis (ruptured or unruptured) or exclusion by digital subtractive angiography (DSA) or by cranial computed tomography angiography (CTA) / magnetic resonance angiography (MRA); 2. Aged ≥ 18 and ≤ 18 years old; 3. With complete demographic data including age and sex; 4. With medical record archiving officially. Exclusion Criteria: 1. Missing data of age, sex or hypertensive status; 2. Age \<18 or \>80 years; 3. Pregnancy; 4. With a history of intracranial arteriovenous malformation, Moyamoya, polycystic kidney disease, Ehlers-Danlos syndrome, Gronblad-Strandberg syndrome, or Marfan syndrome; 5. Suspicion for dissecting or mycotic aneurysms or aneurysm-like lesions that were indistinguishable from the infundibulum, fenestration, dilation, or atherosclerotic remodeling on structural imaging scans.
Where this trial is running
Guangzhou
- Zhujiang Hospital — Guangzhou, China (Recruiting)
Study contacts
- Study coordinator: Chuanzhi Duan, MD, PhD
- Email: doctor_duanzj@163.com
- Phone: 15622311746
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.