Investigating extracellular vesicles in patients with Hairy Cell Leukemia
Hairy Cell Leukemia: Harnessing the Full Power of Extracellular Vesicles to Improve Patient Care Management
This study is testing if tiny particles in the blood of people with Hairy Cell Leukemia can help us understand the disease better and find new ways to track its progress.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna Academic / other |
| Locations | 1 site (Bologna) |
| Trial ID | NCT06764524 on ClinicalTrials.gov |
What this trial studies
This observational study aims to analyze extracellular vesicles (EV) in patients with Hairy Cell Leukemia (HCL) at various stages, including diagnosis, complete remission for over two years, and relapse requiring therapy. By examining the composition of these vesicles, the study seeks to uncover potential biomarkers related to the disease and its biology. The research will involve collecting plasma samples from patients and healthy donors to compare the EV signatures and understand their role in the tumor microenvironment.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with a WHO2022-defined diagnosis of Hairy Cell Leukemia.
Not a fit: Patients who are not diagnosed with Hairy Cell Leukemia or those under 18 years old may not receive any benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to the identification of new biomarkers that improve patient care management for those with Hairy Cell Leukemia.
How similar studies have performed: While the specific approach of analyzing EV in HCL is novel, similar studies in other cancers have shown promise in identifying biomarkers.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria for patients: * WHO2022-defined diagnosis of Hairy Cell Leukemia. * age ≥18 years. * signed informed consent. Inclusion criteria for Healthy Donors: * age ≥18 years. * Volunteers in general good health, free from any disease or serious illness. * Signed informed consent. Exclusion criteria \- None
Where this trial is running
Bologna
- IRCCS Azienda Ospedaliero-Universitaria di Bologna — Bologna, Italy (Recruiting)
Study contacts
- Principal investigator: Lucia Catani, PhD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Study coordinator: Lucia Catani, PhD
- Email: lucia.catani@unibo.it
- Phone: +390512143837
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.