Investigating complications from IV iron in patients with Rendu-Osler disease
Study of Calcium-phosphate Complications Induced by the Administration of IV Iron Supplementation in Patients With Rendu-Osler Disease
This study looks at the problems that might happen when people with Rendu-Osler disease get IV iron, especially focusing on low phosphate levels and bone health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 220 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Strasbourg, France Academic / other |
| Locations | 1 site (Strasbourg) |
| Trial ID | NCT05544669 on ClinicalTrials.gov |
What this trial studies
This observational study examines the complications associated with intravenous iron supplementation in patients suffering from Rendu-Osler disease, particularly focusing on the occurrence of hypophosphatemia and its potential link to osteomalacia. The study aims to gather data on how these complications arise, especially in relation to the excess of FGF-23 and renal phosphate leakage. By analyzing the experiences of patients receiving IV iron, the study seeks to enhance understanding of the risks involved in their treatment.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older diagnosed with Rendu-Osler disease who are currently receiving intravenous iron supplementation.
Not a fit: Patients who are not receiving IV iron supplementation or those who have expressed opposition to participating in the study may not benefit.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients with Rendu-Osler disease receiving IV iron, minimizing complications.
How similar studies have performed: While there have been case reports regarding hypophosphatemia and osteomalacia in similar contexts, this specific observational approach appears to be novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * Major subject (≥ 18 years old) * suffering from Rendu-Osler disease and receiving IV iron supplementation * Subject not objecting, after information, to the reuse of their data for scientific research purposes Exclusion criteria: * Subject who expressed their opposition to participating in the study * Subject under safeguard of justice * Subject under guardianship or curatorship
Where this trial is running
Strasbourg
- Service de Médecine interne - CHU de Strasbourg - France — Strasbourg, France (Recruiting)
Study contacts
- Study coordinator: Murielle RONDEAU-LUTZ, MD
- Email: murielle.rondeau-lutz@chru-strasbourg.fr
- Phone: 33 3 69 55 10 13
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.