Investigating cognitive decline in patients with asymptomatic intracranial stenosis
Investigating the Changes of the Cognition in Asymptomatic Intracranial Stenosis Patients After 1-Year Standard Medical Treatment Without Stenting
This study is trying to see if standard medical treatment for people with asymptomatic intracranial stenosis affects their thinking and memory over a year.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Anhui Medical University Academic / other |
| Locations | 1 site (Hefei, Anhui) |
| Trial ID | NCT04850001 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess cognitive decline in patients with asymptomatic intracranial stenosis after one year of standard medical treatment without stenting. Participants will undergo a series of neuropsychological tests and magnetic resonance imaging (MRI) scans before and after treatment to evaluate changes in cognitive function and underlying neural mechanisms. The study includes approximately 20 patients and 20 healthy controls, with assessments conducted by trained investigators. The goal is to understand the impact of medical treatment on cognitive outcomes in this patient population.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with asymptomatic intracranial stenosis with 50% or more stenosis in the internal carotid artery or middle cerebral artery.
Not a fit: Patients with a history of stroke, transient ischemic attacks, or severe psychiatric illnesses may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into cognitive health management for patients with asymptomatic intracranial stenosis.
How similar studies have performed: While there have been studies on cognitive decline in stroke patients, this specific approach in asymptomatic intracranial stenosis is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with intracranial stenosis which was defined as stenosis of 50% or more in Intracranial segment of internal carotid artery and middle cerebral artery (MCA). * The degree of stenosis was measured by transcranial doppler, computed magnetic resonance angiography (MRA),tomography angiography (CTA) and digital subtraction angiography (DSA). Exclusion Criteria: * History of stroke,transient ischemic attack,seizures or unexplained loss of consciousness. * Organic brain defects on T1 or T2 images. * Any history or clinical signs of other severe psychiatric illnesses (like major depression,psychosis or obsessive compulsive disorder). * Implanted pacemaker,medication pump,vagal stimulator,deep brain stimulator. History of substance abuse within the last 6 months.
Where this trial is running
Hefei, Anhui
- Anhui Medical University — Hefei, Anhui, China (Recruiting)
Study contacts
- Study coordinator: Kai Wang, PhD
- Email: wangkai1964@126.com
- Phone: +86-0551-62922263
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.