Investigating circulating tumor cells in cancer patients
Official title: Circulating Tumor Cells (CTC) in Cancer
Run by University Hospital, Basel, Switzerland · NCT04520672 · Data updated 2026-11-12
This study is testing blood samples from adult cancer patients to see if circulating tumor cells can help us understand their cancer better and predict how they might do in the future.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 3000 (estimated) |
| Sponsor | University Hospital, Basel, Switzerland Academic / other |
| Locations | 2 sites (Basel and 1 other locations) |
| Status | Recruiting |
| Started | October 1, 2020 |
| Main results expected | August 2030 |
| Study ends | August 2030 |
| Registry record updated | March 12, 2025 |
| Trial ID | NCT04520672 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adult patients with a histologically confirmed diagnosis of solid tumors, such as adenocarcinoma or squamous cell carcinoma.
✕Probably not a fit
Patients with blood cancers or those who cannot provide written informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on the collection and analysis of circulating tumor cells (CTCs) from blood samples of adult cancer patients at various stages of their disease. It aims to understand the biology of CTCs and their clusters, evaluating their potential as biomarkers for cancer progression and overall survival. The study will also explore key signaling networks active in CTCs across different cancer types, providing insights into their role in cancer biology.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of cancer progression and improve patient monitoring through the use of CTCs as biomarkers.
How similar studies have gone: Other studies have shown promise in using circulating tumor cells as biomarkers, indicating that this approach has potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult cancer patients * All patients with histology-based proved diagnosis of cancer, all stages and subtypes can be included. Precancerous lesions cannot be included. * All patients with the diagnosis of a solid tumor including adenocarcinoma, squamous cell carcinoma, neuroendocrine carcinoma, sarcoma * Written pathology report must be available. * Written informed consent. Exclusion Criteria: * No written informed consent. * No proved diagnosis of malignancy by pathology report. * Patients with the diagnosis of blood cancer
Where it's running
-
University Hospital Basel
Basel, Switzerland Recruiting -
Department Oncology, Haematology & Immuntherapy, Kantonsspital Baselland
Liestal, Switzerland Recruiting
Study contacts
- Principal investigator: Marcus Vetter, PD Dr. med. — Kantonsspital Baselland, Liestal
- Study coordinator: Marcus Vetter, PD Dr. med.
- Email: marcus.vetter@ksbl.ch
- Phone: +41 61 925 27 15
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Predicting bowel leaks after colorectal surgery with a computer model and surgeon input
This study tests a computer model that predicts anastomotic leaks after colorectal surgery, and sees if adding surgeons’ intuition improves the predictions.
-
Active surveillance after immunotherapy for MMR-deficient colorectal and GI cancers
This study looks at whether some patients with non-metastatic, MMR-deficient or MSI-H colorectal cancers can skip surgery after a strong response to immunotherapy.
-
PCI Registry at University Hospital Basel for Complex Coronary Procedures
This registry collects real-world data from adults undergoing percutaneous coronary interventions at University Hospital Basel to see how different treatments like drug-eluting stents, drug-coated balloons, and bioresorbable scaffolds perform in diverse patients.
-
Severe Complications During VT/PVC Ablation
This study looks at real-world cases to see what severe complications occur during VT or PVC ablations and how patients are managed afterward.
-
Visioning III: Five-year follow-up for MRI-based prostate cancer screening
This study tests a repeat MRI-based screening approach for men who previously had no cancer signs, to see if a negative bpMRI reliably predicts no significant cancer for at least five years.
-
Oxytocin in postmenopausal and premenopausal women
Researchers will test whether cumulative endogenous neurophysin I, a surrogate for oxytocin, differs over a month between premenopausal and postmenopausal women.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.