Investigating chronic endometritis in women with reproductive failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the confounding factors associated with chronic endometritis and the potential therapeutic benefits of antibodies targeting plasma cells in women experiencing reproductive failure. Eligible participants will be recruited from the IVF and miscarriage clinic at the Prince of Wales Hospital/CUHK medical centre. The study will involve endometrial sampling during the mid-luteal phase, with hormonal assessments and ultrasound evaluations to ensure proper timing and conditions for sampling. Immunohistochemical techniques will be employed to quantify plasma cells in the endometrial tissue, which may provide insights into the role of chronic endometritis in infertility.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. Age 20-45 years;
2. Women with a history of 2 or more consecutive miscarriages before 24 weeks of gestation12; or
3. Women who failed to conceive after unprotected intercourse for one year; or
4. Women who failed failure to achieve a clinical pregnancy after two consecutive cycles of IVF, ICSI or frozen embryo replacement cycles where the cumulative number of transferred embryos is no less than four for day-2 embryos and no less than 2 for day-5 embryos (blastocysts), with all embryos being of good quality.

Exclusion criteria

1. Uncorrected uterine anomalies, such as the septate or bicornuate uterus, fibroids (submucous/intramural);
2. Untreated hydrosalpinx;
3. History of antiphospholipid syndrome;
4. Known clinical autoimmune disease;
5. Undergoing immunotherapy;
6. Abnormal thyroid function;
7. Abnormal karyotyping.
8. Those with active pelvic inflammatory disease or suspicion of infection etc.

Where it's running

• The Chinese University of Hong Kong
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Jacqueline Pui Wah Chung, MBBS — Chinese University of Hong Kong
• Study coordinator: Stacey Wong, BSc
• Email: staceywong@cuhk.edu.hk
• Phone: 35051764

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.