Investigating central sensitization in patients with lipedema
Official title: Investigation of the Prevalence of Central Sensitization and Associated Factors in Patients With Lipedema
Run by Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey · NCT06770634 · Data updated 2026-11-12
This study is trying to see if women with lipedema have different pain sensitivity compared to healthy individuals to help improve how the condition is diagnosed and treated.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey Academic / other |
| Locations | 1 site (Istanbul, Üsküdar) |
| Status | Recruiting |
| Started | December 6, 2024 |
| Main results expected | September 1, 2025 |
| Study ends | December 30, 2025 |
| Registry record updated | September 8, 2025 |
| Trial ID | NCT06770634 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include women aged 18 to 65 diagnosed with lipedema or healthy individuals within the same age range without any metabolic issues.
✕Probably not a fit
Patients with concurrent conditions such as lymphedema, chronic venous insufficiency, or those outside the age range may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the presence of central sensitization and its associated factors in patients diagnosed with lipedema, a chronic condition affecting the lower extremities in women. The study will compare pain sensitivity and ultrasonographic findings between lipedema patients and healthy individuals. Participants will undergo various assessments, including pain-pressure threshold measurements and functional scales, to better understand the condition's impact. The findings may contribute to improved diagnosis and treatment strategies for lipedema.
Why it matters
Potential benefit: If successful, this study could enhance the understanding and management of lipedema, leading to better patient outcomes.
How similar studies have gone: While the investigation of central sensitization in lipedema is a relatively novel approach, similar studies in related conditions have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Lipedema; Diagnosis of lipedema Aged between 18 and 65 years Literate Willing to participate in the study 2. control group; Being completely healthy (no internal/metabolic issues such as diabetes, obesity, or hypothyroidism, and no diagnosis of lipedema) BMI ≤ 30 Aged between 18 and 65 years Literate Willing to participate in the study Exclusion Criteria: 1. Lipedema group; Under 18 or over 65 years of age Presence of concurrent lymphedema, chronic venous insufficiency, deep vein thrombosis, polyneuropathy, or fibromyalgia Illiterate Not willing to participate in the study 2. Control group; Under 18 or over 65 years of age Presence of concurrent lymphedema, chronic venous insufficiency, deep vein thrombosis, polyneuropathy, fibromyalgia, systemic rheumatic diseases, active cancer, infections, or pregnancy Illiterate Not willing to participate in the study
Where it's running
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Sultan 2. Abdülhamid Han Eğitim ve Araştırma Hastanesi, İstanbul, Üsküdar 34000
Istanbul, Üsküdar, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Zeynep Candan, MD
- Email: drzeynepcandan@gmail.com
- Phone: drzeynepcandan@gmail.com
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Kinesio Taping Added to Standard Care for Women with Lipedema
This study tests whether adding kinesio taping to usual care helps reduce pain for women with stage II lipedema.
-
Comparison of body composition in lipedema and obesity
This study tests whether women with lipedema have different segmental body fat and muscle distribution compared with BMI-matched women without lipedema.
-
Comparison of Different Exercise Protocols for Lipedema
This study tests whether high‑intensity interval training or moderate‑intensity continuous training improves function, strength, and quality of life in adults with lipedema.
-
taVNS-enriched rehab for lipedema
This study tests whether adding transcutaneous auricular vagus nerve stimulation (taVNS) to standard rehabilitation helps people with lipedema reduce symptoms.
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Manual and self-lymphatic drainage with exercise for lipedema
This study tests whether manual lymph drainage plus supervised exercise works better than self-lymph drainage plus guided activity for reducing pain and improving function in women with lipedema over six weeks.
-
Turkish version of the Duke Activity Status Index in women with lipedema
This study tests whether the Turkish Duke Activity Status Index accurately and consistently measures functional capacity in women with lipedema.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.