Investigating cardiovascular risk in patients with digital osteoarthritis

Assessment of Cardiovascular Risk in Digital Osteoarthritis: A Case-control Study.

This study is testing whether people with digital osteoarthritis have a higher risk of heart problems compared to those without the condition.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 100 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: University Hospital, Clermont-Ferrand (Academic / other)
• Locations: 1 site (Clermont-Ferrand)
• Trial ID: NCT05923736 on ClinicalTrials.gov

What this trial studies

This study aims to compare cardiovascular risk between patients with digital osteoarthritis and a control group without osteoarthritis. Participants will undergo ultrasound scans to measure carotid intima-media thickness, along with clinical assessments by rheumatologists and cardiovascular risk evaluations. The goal is to understand how digital osteoarthritis may impact cardiovascular health. This cross-sectional case control study will provide insights into the relationship between osteoarthritis and cardiovascular conditions.

Who should consider this trial

Good fit: Ideal candidates include adults diagnosed with digital osteoarthritis who meet specific ACR criteria and have radiographic signs of the condition.

Not a fit: Patients with conditions unrelated to osteoarthritis or those who do not meet the inclusion criteria may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved cardiovascular risk management for patients with digital osteoarthritis.

How similar studies have performed: While there may be studies on cardiovascular risks in osteoarthritis, this specific approach focusing on digital osteoarthritis is relatively novel.

Eligibility criteria

Inclusion Criteria:

For all subjects:

* Adult male or female subject
* Able to give informed consent to participate in research
* Affiliated with a Social Security plan

For the digital osteoarthritis group:

* Consultant in Rheumatology at Clermont-Ferrand University Hospital
* Affected by digital osteoarthritis meeting ACR diagnostic criteria with radiographic signs of osteoarthritis validated by a radiologist.

For the control group :

* Rheumatology consultant at the Clermont-Ferrand University Hospital or hospitalized in this department for a non-arthritic, non-rheumatic pathology.
* Patients with spinal disc pathology (lumbago, radiculalgia due to disco-radicular conflict) or non-severe osteoporosis, i.e. with a densitometric T score between -2.5 and -3 DS.

Exclusion Criteria:

For all topics :

* Refusal to participate
* Pregnant women, nursing mothers
* Subjects under guardianship or curatorship, deprived of liberty, or under court protection

For the digital osteoarthritis group:

\- Existence of diagnostic arguments for another inflammatory rheumatism (rheumatoid arthritis, spondylarthritis, psoriatic arthritis, lupus, gout, chondrocalcinosis...) or another arthrosic localization (gonarthrosis, coxarthrosis, discarthrosis) symptomatic at the time of inclusion or affecting daily activities.

For the control group :

* Existence of chronic inflammatory rheumatism (rheumatoid arthritis, spondylitis, psoriatic arthritis, lupus, gout, chondrocalcinosis...)
* Existence of digital osteoarthritis
* Existence of another painful arthritic site (knee, hip, rachi) Existence of finger pain, whatever the etiology.

Where this trial is running

Clermont-Ferrand

• Chu Clermont Ferrand — Clermont-Ferrand, France (Recruiting)

Study contacts

• Principal investigator: Sylvain Mathieu — University Hospital, Clermont-Ferrand
• Study coordinator: Lise Laclautre

Conditions Osteoarthritis Hand; Lumbago; Osteoporosis; Radiculopathy Lumbar