Investigating cardiovascular risk after preeclampsia
Endothelial Dysfunction and Cardiovascular Risk After Preeclampsia
This study looks at the heart health risks for women who had preeclampsia during pregnancy, comparing them to women who had healthy pregnancies, to see how it affects them years later.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | Female |
| Sponsor | Charite University, Berlin, Germany Academic / other |
| Locations | 1 site (Berlin) |
| Trial ID | NCT05277233 on ClinicalTrials.gov |
What this trial studies
This observational study examines the cardiovascular risks faced by women 5-15 years after experiencing early or late-onset preeclampsia. It utilizes advanced techniques such as adenosine stress Magnetic Resonance Imaging and non-invasive assessments like retinal vessel analysis and flow-mediated dilation to compare these women with those who had healthy pregnancies. The goal is to better understand the long-term cardiovascular implications of preeclampsia.
Who should consider this trial
Good fit: Ideal candidates are women aged 18-60 who are 5-15 years postpartum following a preeclampsia diagnosis.
Not a fit: Patients with certain medical conditions such as atrioventricular block, chronic obstructive pulmonary disease, or those who are currently pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved monitoring and management strategies for women at risk of cardiovascular disease after preeclampsia.
How similar studies have performed: While this study explores a specific aspect of cardiovascular risk post-preeclampsia, similar studies have shown promising results in understanding long-term health outcomes in women after pregnancy complications.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women * 18-60 years * 5-15 years postpartum Exclusion Criteria: * Atrioventricular block, chronic obstructive pulmonary disease, bronchial asthma * Pregnancy and/or active breastfeeding * Glaucoma disease, epilepsy * In addition for MRI: metal implants, electric devices, intolerance of contrast media, claustrophobia, renal or hepatic dysfunction (GFR \< 30 ml/min)
Where this trial is running
Berlin
- Experimental and Clinical Research Center — Berlin, Germany (Recruiting)
Study contacts
- Principal investigator: Anja Mähler, PhD — Charite University, Berlin, Germany
- Study coordinator: Kristin Kräker, PhD
- Email: kristin.kraeker@charite.de
- Phone: +49 30 450540 328
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.