Investigating brain activity related to walking in Parkinson's patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the neural mechanisms involved in movement among individuals with Parkinson's disease. Participants will engage in walking and gait-related tasks while their brain activity is recorded to identify neural biomarkers associated with gait. The study includes 60 participants, split evenly between healthy individuals and those with Parkinson's disease, to compare neural activity during different motor tasks. Insights gained may lead to personalized treatment options for managing gait disorders in Parkinson's patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

All participants

* must have given informed consent as documented by signature
* agree to comply with the study procedures

Healthy control group

* no neurological, orthopedic, or rheumatologic disease history
* no identified sensory impairment.
* no epilepsy and self-diagnosed acute or chronic psychiatric disorders

Parkinson's Patients

* non-tremor dominant idiopathic PD patients
* presence of postural instability (UPDRS \>1 for postural instability \[17\]), gait disturbance, and absence of other causes of reduced balance
* Implanted with Percept™ PC neurostimulator
* Able to be in the stimulation OFF

Exclusion Criteria:

* Relevant cognitive impairment, with a score on Montréal Cognitive Assessment (MoCA) \< 20
* History of physical or neurological condition that interferes with study procedures
* Social and/or personal circumstances interfering with the ability to come to the session

Where it's running

• Cereneo
  Vitznau, Canton of Lucerne, Switzerland Recruiting

Study contacts

• Principal investigator: Olivier Lambercy, PhD — RELab, ETH Zürich
• Study coordinator: Lena Salzmann, MSc
• Email: lena.salzmann@hest.ethz.ch
• Phone: +41788248679

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.