Investigating brain activity related to impulsivity in REM sleep behavior disorder and Parkinson's disease
Neural Correlates of Impulsivity in Idiopathic REM Sleep Behavior Disorder: a Functional Magnetic Resonance Imaging Case-control Study
Chinese University of Hong Kong · NCT05353855
This study is testing how brain activity related to impulsivity differs in people with REM sleep behavior disorder and Parkinson's disease compared to healthy individuals.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 96 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | Chinese University of Hong Kong (other) |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT05353855 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the neural correlates of impulsivity in individuals with idiopathic REM sleep behavior disorder (iRBD) and Parkinson's disease (PD) using functional Magnetic Resonance Imaging (fMRI). It will compare brain structures and connectivity in healthy controls, patients with iRBD, and PD patients, both on and off dopaminergic medication. The study will assess differences in brain activity in response to impulsivity tasks and measure structural changes in key brain areas associated with impulsivity. A total of 96 subjects will be recruited for this case-control study.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with idiopathic REM sleep behavior disorder, Parkinson's disease, or healthy controls matched by age and sex.
Not a fit: Patients with a history of impulsive-compulsive disorders, narcolepsy, or other neurodegenerative diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the neural mechanisms of impulsivity, potentially leading to better management strategies for patients with Parkinson's disease.
How similar studies have performed: While studies have explored impulsivity in Parkinson's disease, this specific investigation into iRBD as a prodromal stage is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age-and sex-matched with the groups; 2. Being capable of giving informed consent for participation of the study; 3. Without a personal history or a family history of PD or RBD; 4. A total score on REM Sleep Behavior Questionnaire (RBDQ-HK) less than 19, which is the suggestive cut-off of a diagnosis of RBD; 5. Absence of self-report dream enactment behaviors and RSWA as measured by v-PSG Exclusion Criteria: 1. Having a history of ICD diagnosis or ICD symptom(s) assessed with Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS); 2. Presence of narcolepsy or other neurodegenerative diseases (except for PD group) that may give rise to RBD; 3. Presence of mood disorder which may have great impact on impulsivity; 4. A total score of the Montreal Cognitive Assessment (MOCA) ≤ 22 and the Clinical Dementia Rating (CDR) ≥ 1, indicating dementia; 5. Except for early medicated PD patients, if subjects from other groups who are on medication that may induce impulsivity, such as dopaminergic medication, will be excluded; 6. Contraindication to MRI (e.g., presence of implants or claustrophobia).
Where this trial is running
Hong Kong
- The Chinese University of Hong Kong — Hong Kong, Hong Kong (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Parkinson Disease, Impulsivity, Prodromal Parkinson's disease, REM sleep behavior disorder, Functional Magnetic Resonance Image