Investigating body composition's impact on rehabilitation outcomes
Correlations of Body Composition Measures with Functional Outcomes and the Clinical Frailty Scale in Inpatient Rehabilitation: a Prospective Cohort Study
Changi General Hospital · NCT06527742
This study is looking to see how body composition, like muscle and fat levels, affects recovery for patients in rehab after conditions like stroke or lung disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 345 (estimated) |
| Ages | 21 Years and up |
| Sex | All |
| Sponsor | Changi General Hospital (other) |
| Locations | 1 site (Singapore, Singapore) |
| Trial ID | NCT06527742 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between body composition measures, such as muscle mass, body fat, and phase angle, and functional outcomes in patients undergoing inpatient rehabilitation. Patients with conditions like stroke, deconditioning, or lung disease will be monitored using frailty-specific tools and a body composition monitor. The study will track these patients from admission to discharge, collecting baseline and follow-up data to assess the correlation between body composition and rehabilitation success.
Who should consider this trial
Good fit: Ideal candidates include patients with stroke, deconditioning, lung disease, or lower limb amputations who are medically stable and undergoing inpatient rehabilitation.
Not a fit: Patients with pacemakers, certain medical devices, abnormal fluid status, or cognitive/physical impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved rehabilitation strategies tailored to individual body composition profiles.
How similar studies have performed: While similar studies have explored body composition in rehabilitation, this specific approach focusing on frailty and functional outcomes is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Transferred under the Rehabilitation Medicine service for post-acute rehabilitation 2. Rehabilitation diagnosis of: 1. Stroke with motor weakness (modified Rankin scale 1-5), or 2. Deconditioning (from sepsis, post-ICU admission, heart failure, falls, musculoskeletal conditions with or without pain, or other conditions), or 3. Pulmonary rehabilitation (with or with long-term oxygen therapy), or 4. Lower limb amputees (transtibial or transfemoral) 3. Medically stable 4. Able to understand English consent form or suitably-translated document, or have a family member/legally-authorised representative who is able to do so and willing to provide consent Exclusion Criteria: 1. Pacemaker or implantable defibrillator in-situ 2. Medical devices or surgical implants that will interfere with BIA measurement per the manufacturer's guidelines 3. Abnormal fluid status (overloaded or depleted) at the point of screening 4. Cognitive or physical inability to tolerate sitting/lying still for 2mins (for BIA measurement)
Where this trial is running
Singapore, Singapore
- Changi General Hospital — Singapore, Singapore, Singapore (RECRUITING)
Study contacts
- Principal investigator: Edmund JR Neo, MBBS — Singapore Health Services Pte Ltd
- Study coordinator: Edmund JR Neo, MBBS
- Email: edmund.neo.jin.rui@singhealth.com.sg
- Phone: 065 6936 6462
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Frailty, Stroke, Debility Due to Disease, Sarcopenia, Deconditioning, Body fat, Skeletal muscle mass, Phase angle