Investigating blood parameters and clotting in sickle cell disease
Study of Erythrocyte Parameters and Hypercoagulability in Sickle Cell Disease
This study is trying to see if certain blood tests can help predict painful crises in people with sickle cell disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Rouen Academic / other |
| Locations | 1 site (Rouen) |
| Trial ID | NCT05376046 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between erythrocyte parameters and hypercoagulability in patients with sickle cell disease (SCD). By measuring routine laboratory biomarkers of hemolysis, the study seeks to determine if these can predict the occurrence of vaso-occlusive crises (VOC) in individuals diagnosed with SCD. The research will involve assessing reticulocyte counts and conducting thrombin generation assays to gather relevant data. The findings could enhance understanding of SCD complications and improve patient management.
Who should consider this trial
Good fit: Ideal candidates for this study are adults diagnosed with sickle cell disease.
Not a fit: Patients under 18 years, pregnant individuals, or those under protective guardianship will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better prediction and management of vaso-occlusive crises in sickle cell disease patients.
How similar studies have performed: While there have been studies on sickle cell disease, this specific approach of combining erythrocyte parameters with thrombin generation assays is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Sickle cell disease Exclusion Criteria: * \<18 years * pregnancy * Patient under protective guardianship or curatorship
Where this trial is running
Rouen
- Rouen university Hospital — Rouen, France (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.