Investigating blood flow restriction effects on pain and strength in carpal tunnel syndrome patients

Effect of Blood Flow Restriction on Pain Perception, Grip Strength and Nerve Conductivity in Patients With Carpal Tunnel Syndrome: A Randomized Controlled Trial.

Not applicable Interventional Cairo University · NCT06574841

This study is testing if adding blood flow restriction training to regular physical therapy can help people with carpal tunnel syndrome feel less pain and get stronger.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment30 (estimated)
Ages30 Years to 55 Years
SexFemale
SponsorCairo University Academic / other
Locations1 site (Cairo)
Trial IDNCT06574841 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to explore the impact of blood flow restriction (BFR) training on pain perception, grip strength, and nerve conductivity in patients with carpal tunnel syndrome (CTS). Participants will be divided into two groups: one receiving conventional physical therapy and the other receiving BFR training alongside the same therapy. The study will assess whether BFR can reduce pain and improve grip strength without affecting nerve conduction velocity. The methodology includes clinical assessments and physical therapy interventions tailored to CTS symptoms.

Who should consider this trial

Good fit: Ideal candidates are females aged 30-55 diagnosed with carpal tunnel syndrome and exhibiting specific clinical symptoms.

Not a fit: Patients who have undergone carpal tunnel release surgery or have other significant medical conditions such as diabetes or cardiovascular disorders may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could provide a novel non-invasive treatment option to alleviate pain and enhance grip strength for patients with carpal tunnel syndrome.

How similar studies have performed: While the use of blood flow restriction training is gaining attention, this specific application in carpal tunnel syndrome is relatively novel and has not been extensively tested in prior studies.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. patients diagnosed by a physician according to the American Academy of Orthopedic Surgeon with carpal tunnel syndrome (CTS).
2. age:30-55 years old.
3. females.
4. positive clinical provocative tests for CTS (Tinel test and Phalen test).
5. subjects with a history of paresthesia, numbness, or pain in the median nerve distribution, night waking, and nocturnal pain.

Exclusion Criteria:

1. subjects who had carpal tunnel release surgery.
2. subjects with cervical disc prolapse.
3. subjects with cervical spondylosis.
4. subjects with thoracic outlet syndrome (TOS).
5. subjects with diabetes.
6. subjects with gestational diabetes.
7. subjects with cardiovascular disorders.
8. subjects with hypertension.
9. pregnant women.

Where this trial is running

Cairo

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Carpal Tunnel SyndromeCarpal Tunnel Syndrome, Blood Flow Restriction.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.