Investigating bitter taste receptors in oropharynx cancer
Expression of Bitter Taste Receptors in Oropharynx Carcinoma
NA · Technische Universität Dresden · NCT05211427
This study is trying to see if bitter taste receptors in the throat are different in patients with oropharyngeal cancer compared to healthy people, which could help find new treatments.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Technische Universität Dresden (other) |
| Locations | 1 site (Dresden, Saxony) |
| Trial ID | NCT05211427 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the expression of bitter taste receptors in patients with p16-positive and negative oropharyngeal carcinomas compared to healthy tissue. The hypothesis is that these carcinomas express TAS2Rs, and their stimulation may induce apoptosis. The study will involve a pilot group of 20 patients, including those with oropharyngeal squamous cell carcinoma and benign pharyngeal conditions, using qPCR and taste tests to analyze receptor expression and function. The findings could enhance understanding of oropharyngeal cancers and lead to new therapeutic approaches.
Who should consider this trial
Good fit: Ideal candidates include patients diagnosed with p16-positive or negative oropharyngeal squamous cell carcinoma.
Not a fit: Patients with conditions unrelated to oropharyngeal cancer or those who do not meet the inclusion criteria may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could provide new insights into treatment strategies for oropharyngeal cancer.
How similar studies have performed: While this approach is novel, similar studies investigating taste receptors in cancer have shown potential for new therapeutic insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Oropharynx SCC for the patient group * signed informed consent for all Exclusion Criteria: -
Where this trial is running
Dresden, Saxony
- Smell and Taste Center, University Klinik Dresden — Dresden, Saxony, Germany (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Oropharynx Cancer