Investigating biomarkers in unstable carotid plaque
EVALUATION OF NEW BIOMARKERS IN THE IDENTIFICATION OF UNSTABLE CAROTID PLAQUE
This study is trying to see if certain markers in the blood can help understand the risks of heart problems in people with narrowed carotid arteries and different types of plaque.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS Academic / other |
| Locations | 1 site (Roma, RM) |
| Trial ID | NCT06887894 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationships between circulating microRNAs and both symptomatic and asymptomatic internal carotid artery stenosis (ICAS), as well as the morphology of carotid plaques and the occurrence of future cardiovascular events. Participants will undergo carotid endarterectomy, allowing researchers to collect data on their plaque characteristics and associated biomarkers. The study focuses on understanding how these biomarkers may correlate with the severity of carotid artery diseases and potential cardiovascular risks.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old with significant internal carotid artery stenosis who are referred for carotid artery endarterectomy.
Not a fit: Patients with significant internal carotid artery stenosis who are referred for carotid artery stenting may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved risk assessment and management strategies for patients with carotid artery diseases.
How similar studies have performed: While there have been studies investigating biomarkers in cardiovascular diseases, this specific approach focusing on miRNAs and unstable carotid plaque is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Presence of significant internal carotid artery stenosis referred to carotid artery endarterectomy. * Age\>18 years Exclusion Criteria: * Presence of significant internal carotid artery stenosis referred to carotid artery stenting
Where this trial is running
Roma, RM
- Fondazione Policlinico Universitario A. Gemelli IRCCS — Roma, Rm, Italy (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.