Investigating B7-H4's Role in Glioma Vaccine Response

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on glioma patients to explore the role of B7-H4 in the resistance to therapeutic cancer vaccines. It aims to understand how B7-H4 overexpression in macrophages correlates with decreased T cell infiltration and vaccine efficacy. By analyzing tissue samples from glioma patients, the study seeks to uncover the mechanisms behind vaccine resistance, potentially leading to improved treatment strategies. The research is conducted at Huashan Hospital, where eligible patients will provide informed consent for participation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Inclusion Criteria:

The patients with glioma in the Department of Neurosurgery of Huashan Hospital Affiliated to Fudan University who meet the following three conditions can be enrolled

1. They were 18-80 years old, male and female;
2. The pathological results of frozen section during operation were gliomas;
3. Tissue (6 mm \* 6 mm) can be used for cell sorting on the basis of not affecting clinical routine diagnosis;
4. Sign informed consent.

Exclusion Criteria:

Patients who meet any of the following criteria will not be included in this study:

1. Participants in other clinical trials;
2. Pregnant women.

Where it's running

• Di Chen
  Shanghai, Shanghai Municipality, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.